الخلاصة:الكلكتين-4  هو واحد من العائلة البروتينية المرتبطة بالكلايكوسيدات نوع  بيتا و التي تتعرف على مجموعة متنوعة من البروتينات التي تحوي الكلايكان على سطح الخلية وتفرز بغزارة في الأورام المختلفة، بما في ذلك سرطان المعدة.

ارتبطت غزارة الكلكتين -4  فضلا عن التغيرات في توزيعها التحت خلوية مع تطور سرطان المعدة وسوء مأّل الحالة قد توفر المعلمات الجزيئية التش

الملخص : تم الكشف عن الأجسام المضادة السيتوبلازمية المضادة للمتعادلة ( ANCA ) للمجموعات الفرعية الثانوية ( ايلاستيز ، اللايزوزايم ، كاثيبسين ج ، اللاكتوفيرين و BPI ) بين مرضى داءالذئبة الاحمراري تسبب التهاب الأوعية الدموية : .داء الذئبة الاحمراري ( SLE ) هو مرض معقد المناعي والتي تتميز بإنتاج الأجسام المضادة المفرط، و تشكيل مجاميع مناعية، و إصابة الأنسجة بوساطة مناعيا .

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خلفيه البحث : يعتبر المفراس احد التقنيات التشخيصيه للاورام المحورية للحفرة القحفية الخلفية  لانه يستطيع تحديد موقع حجم وشكل الورم كما يظهر تاثير الورم على المنطقه المحيطه به .

الهدف : لتقييم المفراس متعدد الطبقات بالنسبه للاورام المحورية للحفرة القحفية الخلفية  ومقارنه النتائج مع نتائج الفحص النسيجي .

المرضى و طرائق العمل : هذه

الخلفية: الإنتان الجرثومي في الأطفال حديثي الولادة سبب مهم ومتكرر للمراضة والوفيات في الأطفال الحديثي الولادة بالأخص في الدول النامية وحديثي الولادة قليلي الوزن .

الهدف : هدف الدراسة هو لتحديد العلامات السريرية, عوامل الخطر,المصاحبة للإنتان في الحديثي الولادة ولتقييم نسبة الوفيات الناتجة من الإنتان في الحديثي الولادة وعلاقته مع الوزن عند الولادة, عمر الحمل,بداية الإنتان ,نوع

Background: Diabetic retinopathy is an important complication of diabetes mellitus. It is supposed that elevated sialic acid in diabetes mellitus plays an important role in diabetic retinopathy. This study investigated serum total sialic acid levels related to glycemic control, blood pressure, retinopathy, and serum lipid level in diabetic retinopathy patients.
Patients & Methods: Type 2 diabetic patients aged (56.47±10.68) years were recruited for the study. Fasting venous blood samples were collected from 132 diabetic subjects of whom 79 without retinopathy and 53 were diabetic with retinopathy. All the blood samples were processed for serum total sialic acid (TSA), fasting serum glucose (FSG), HbA

Background: Uncontrolled tumor cell proliferation is a reality in tumor cells, and the progression from a normal cell into a transformed cell probably includes genetic events affecting checkpoints in the cell cycle machinery.
Materials and methods: This study investigated the immunoexpression of p16INK4a in the paraffin sections from 43-cancers of colorectal tissue (CRC),26-hyperplastic polyps and adenomas(CRHPA) and 35-normal tissues (CRN),using immunohistochemical assay. We correlated the expression patterns with tumor histopathological type, site of the tumor, distance metastasis according to the TNM system.
Results: In colorectal cancer (CRC) patients’ p16INK4a,immunoexpression was detected in 32

Background: Cerebral palsy is a disorder of movement and posture resulting from permanent, nonprogressive defect or lesion of the immature brain. Spastic cerebral palsy is a common clinical type which is difficult to diagnose clinically in the early years of life. This study was conducted to identify the changes in the H-reflex excitability in children with spastic cerebral palsy as compared to normal children.
Methods: The excitability of the monosynaptic H-reflex pathway was tested in 36 children with spastic cerebral palsy during waking by calculation of the H-reflex wave amplitude with the ratio of maximal H /maximal M response amplitudes and compared with 32 normal children of the matching age.

Background: Cholestatic Jaundice is a dilemma facing not only the primary care provider but also the specialist pediatricians in our country.
Subjects & methods: Analysis of 50 cases of cholestatic jaundice aged 3 weeks- 18 months were carried out over 18 months in the Gastroenterology & Hepatology unit in the Children Welfare Teaching Hospital, Medical City, and Baghdad. Clinical, biochemical, radiological and histopathological results were recorded.
Results: Fifty patients with Cholestatic Jaundice, 28 males &22 females, were evaluated. The main causes of Cholestatic Jaundice were Biliary Atresia in 22 cases (44%)(the mean age of presentation was 4.1 months ), and Neonatal Hepatitis Syndr

الخلاصه :

ذات الرئه المكتسبه مجتمعيا واحده من اهم الالتهابات التنفسيه المسببه للوفاه. لذا استحدث هذا المعيار للسرعه تصنيف وتشخيص الالتهابات الصدريه لضمان سرعه التشخيص واعطاء القرار الصائب في العلاج السريع, لتجنب المضاعفات الخطيره للمرض .

الغرض من الدراسه: لبيان مدى فاعليه استخدام معيار الكيرب 65 في تقيم وتشخيص شده الاصابه بالتهاب ذات الرئه المكتسبه مجتمعيا لد

Background: the first stage ,labour is divided into early (latent phase )when uterine contractions are irregular and cervical effacement and dilatation are gradual, while the active phase of labour commences when cervical dilatation reaches (4) cm .and uterine contractions are more powerful . Our aim from this study is to see the effect of the timing of admission to labour room on mode of delivery and foetal outcome.
Patients and method: 240 nulliparous women at term pregnancy were diagnosed as labour pain and admitted to Baghdad Teaching Hospital from the first of January to the end of December 2006, they were followed during their course of labour to see the effect of admission to the labour room in&nbs

Background: The purpose of the study is to determine whether the pre-treatment clinical systemic variables and optical coherence tomographic (OCT) findings are associated with the subsequent response to the intravitreal Bevacisumab (IVB) in eyes with diabetic macular edema (DME).
Patients and Methods: 38 patients (45 eyes) with refractory diabetic macular edema. ; 16 females, 22 males and mean age was 57.5 year. All patients had DME not responded to other treatments. Complete eye examination; BCVA* (represented as LOGMAR for adequate statistical analysis), slitlamp exam, intraocular pressure measurement, stereoscopic biomicroscopy of the macula, and morphologic patterns of diabetic macular edema demonstra

Background: Aphaeresis is a term that means to separate or to take away. The basic idea of aphaeresis is efficient removal of a circulating cellular blood component, either cells (Cytopheresis) or plasma solute (plasmapheresis, plasma exchange).Thus, the treatment goal of aphaeresis is to remove the circulating cell or substance directly responsible for the disease process. Acceleration and development of aphaeresis applications had taken place with the arrival of automated cell separators in 1970s that ensure selectively removal of one or more of blood components from the blood and return the remainder to the individual. Plasmapheresis is separation of plasma from blood cells which are returned to the body.

Background: Cervical erosion (CE) is a common finding on routine pelvic examination during the fertile years. Published articles on CE in Iraq are scarce; therefore this study was carried out.
Methods: A total of 100 non pregnant women had CE attending a private clinic in Al-Sader city, Baghdad, was included in this study. Pelvic examination was done; demographic data and gynaecological history were obtained.
Results: The age of women was 27.1 ± 5.9 years with 7.3 ±2.9 educational years. Mucopurlent vaginal discharge was a complaint in 49% of women, and a watery vaginal discharge was a complaint in a similar percent. Thirty four of women were oral contraceptive users and 11% were using intrauterine c

Background: The problem of excessive alcohol consumption is a major cause of public health concern in most countries of the world today. Royal Colleges of Physicians and Psychiatrists recommended that every inpatient should be screened with a questionnaire for alcohol related problems. Therefore, this work was carried out to report on alcoholism in the emergency unit in two general hospitals in Baghdad, Iraq.
Methods: The study was carried out in Al-Sader general hospital (Al-Sader city, Baghdad) and Baghdad teaching hospital (Baghdad) for the period 1st July 2008 to 1st May 2009. Data collection was two days per week. Version of 25 items Michigan Alcoholism Screening Test (MAST) and semi-structured 

Background: Although studies regarding the role of religious beliefs in psychological well being are relatively recent, the importance of people’s religiousness and spirituality for their health status has been widely acclaimed based on hundreds of published studies.
Patients and Methods: The Arabic Modified version of WHOQOL-SRPB (World health organization quality of life-spirituality, religiosity and personal belief) questionnaire was self
administered to a systematic random sample of 100 fifth year medical students.
Results: Around a quarter (21-28%) of subjects perceived religiousness as very to extremely important. This percentage raised to 38% for spirituality and further to 61% for personal believes.

Background: The electrocardiographic QT interval has been extensively studied in diabetes mellitus. Recently, there has been increasing interest in the relationship between diabetes and QT abnormalities .The QT interval, which is easily obtained from a standard resting electrocardiogram( ECG), reflected the total duration of ventricular myocardial depolarization and repolarization. The heart rate corrected QT interval (QTc) by Bazett's formula on the electrocardiogram has been proposed as a risk factor for ventricular arrhythmias in diabetes mellitus. Dispersion of QT(QTd) is defined as the difference between maximum and minimum QT interval QT interval on 12 lead ECG, which reflected spatial ventricular

Background; this study is designed to assess the effect of religious and spiritual beliefs on quality of life among two groups of university students in Iraq and Jordan.
Objective: to examine the psychological impact of religious and spiritual beliefs on quality of life and to implement the Quality of Life- Spiritual Religious and Personal Beliefs(QOL-SRPB)
questionnaire for the first time in both countries .
Method :A convenient sample of advanced medical students from Baghdad college of Medicine in Iraq and College of Medicine in University of Science and Technology in Jordan recruited during April 2008 to complete 200 forms of the Arabic modified version of QOL-SRPB simultaneously.
Results: Analysis of

Background: Dysentery is an important cause of morbidity and mortality associated with diarrhea. About 10% of all diarrheal episodes in children less than 5 years are dysenteric, but these cause about 15% of all deaths attributed to diarrhea.
Objective : To demonstrate the most common pathogens causing bloody diarrhea in children between 2 months and 5 years old, to describe some of the associated factors accompanying bloody diarrhea and to highlight the most important clinical features.
Patients and methods: A descriptive study of 82 children, between the age of 2 months to 5 years with bloody diarrhea, who were admitted to the Children Welfare Teaching Hospital/ Medical City/Baghdad during the period betw

Background: Hypoxic ischemic encephalopathy (HIE) means failure to establish effective spontaneous breathing after complete delivery & leads to many changes if not diagnosed or treated immediately as mental retardation, cerebral palsy and epilepsy.
Objective: to study the demographic and clinical predictors of perinatal outcome in full term neonates with hypoxic ischemic encephalopathy.
Methods: Forty two neonates were diagnosed as cases of hypoxic ischemic encephalopathy by specialist pediatricians & admitted in Children Welfare Teaching Hospital & Al Kut Hospital in the period from January 2008 to March 2009. Predictors studied were sex, birth weight, Apgar scores at 1,5,15 min., meconium

خلفية البحث : تحديد الدراسات الشعاعية التي يجب اجرائها بعد تشخيص التهابات المجاري البولية عند الاطفال هي محل خلاف علمي 

اهداف الدراسة :دراسة الموجودات الاشعاعية عند الاطفال المصابون بالتهابات المجاري البولية المتكررة 

طرائق العمل : شملت الدراسة (104) اطفال مصابون بالتهابات المجاري البولية , اجريت لهم فحوصات التشخيص بالامواج فوق الصوتية ( السونار ) لجميع ال

Background: All medical colleges give students courses in epidemiology and biostatistics to help them in understanding medical data and to prepare them to conduct graduate and professional research. After graduation, understanding and correct application of the principles of epidemiology and biostatistics help the physicians in making better diagnostic and management decision based on best evidence.
Patients and Methods: A cross-sectional questionnaire-based survey was carried out among junior (chronic resident) doctors at several hospitals in Baghdad from the 1st of January till the 31st October 2009. A total of 212 physicians answered the questionnaire which covered demographic characteristics, average score

Background: Population studies suggest that 3–8% of asymptomatic adults have thyroid nodules. Nodules have a 5–15% prevalence of malignancy. Fine-needle aspiration cytology is the primary and frequently initial tool for assessing the risk of malignancy in thyroid nodules and selecting patients for thyroid surgery.
Patients and Methods: This prospective study was done during the period from June 2007 to November 2008. The study includes 141 patients with palpable solitary or multiple thyroid nodules. Only patients with normal or low TSH values were referred for ultrasound examination and ultrasound guided FNAC, which were done using fine needles (G 20).
Results: eleven patients (7.8%) have insuffici

Background: Extradural hematoma (epidural hematoma) result from tearing of dural or skull vessels caused by deformation of the skull or fracture. Epidural hematoma can occur at all ages but are seen primarily in patients younger than 60 years.
Patients and Methods: this prospective study was conducted on 50 patients (38 male, 12 female) suffering from head injury and has a CT scan evidence of extradural hematoma during the period from 1 January 2006 to 31 December 2008 in Neurology surgery hospital.
Results: There were 4 patients above 50years, the cause of injury was fall in50%, assault24%, RTA20%and bullet injury 6%.the commonest site was temporal region 42%.surgical treatment were done to 39 patient

Background: The coexistence of renal and heart failure carries an extremely bad prognosis. The exact cause of deterioration of kidney function and the mechanism underlying this interaction are complex, multifactorial in nature, and still not completely understood. Both the heart and the kidney act in tandem to regulate blood pressure, vascular tone, diuresis, natriuresis, etc.
Patients and methods: Sixty patients mean age 65.5 year were complaining heart failure duo to different causes assessed for renal function (blood urea &creatinine) and cardiac function by echocardiography in day 0 and 10 day after treatment of heart failure.
Results: The mean value (±S.D) of blood urea and serum creatinine on day 0 were 64.17mg/dL (±30.

Background: Several factors render chronic lymphocytic leukemia (CLL) an interesting subject for study by researchers. These include marked progress in understanding the molecular biology of normal and neoplastic lymphocytes and recent advances in molecular genetics techniques. Among molecular markers, p53 cancer suppressor gene and the antiapoptotic gene Bcl-2 have been widely studied. 
Patients and methods: A retrospective cross-sectional study done on 60 patients with chronic lymphocytic leukemia compared with 20 controls (anemic patients), all recruited at the Medical City Teaching Hospital laboratories from January 2004 to December 2007. The bone marrow biopsy of each was re-examined histologica

Background: Except for the tight correlation to nasopharyngeal carcinoma, accumulating evidences show that Epstein-Barr virus (EBV) is correlated to other carcinomas. This study was to investigate the association of EBV with colorectal tumors.
Materials & methods: Forty paraffin embedded blocks of colorectal tumors (thirty were adenocarcinoma and ten were benign tumors) were all examined for the presence of EBV DNA with
the application of In Situ hybridization.
Results: In Situ EBV DNA signals was detected in 6 out of 30 (20%) of colorectal carcinoma with no observed signals in the sections from benign group.
Conclusion: Our results showed that infection of EBV exists in human colorectal adenocarcinoma

Background: Idiopathic autoimmune thrombocytopenia purpura (ITP) is an isolated thrombocytopenia in a patient with no clinically apparent associated conditions or factors that can
cause thrombocytopenia. The syndrome of ITP is caused by platelet-specific auto-antibodies that bind to autologous platelets. The diagnosis of ITP is usually a diagnosis of exclusion based on a demonstration of peripheral thrombocytopenia. Steroids are the conventional first-line therapy for adult ITP. Most patients demonstrate a response to steroids within 2 to 4 weeks, but a late response is possible.
Patients and Methods: A prospective study on 50 patients with diagnosis consistent with ITP, initially treated by steroid, p

Background: Seizures in the neonatal period are common. They can present as focal clonic, focal tonic, myoclonic, generalized tonic and subtle seizures. They can be caused by a variety of
conditions, ranging from benign self-limited illnesses to severe life-threatening disorders.
Patients and methods: A prospective study included 75 neonates with seizures in the first 28 days of life were admitted to neonatal care unit in Children Welfare Teaching Hospital from January 15th 2009 to August 15th 2009. A Full history was obtained and patients were examined by a specialist in the neonatal care unit and the researcher. Laboratory investigations and neuroimaging studies were done for all patients.
Results: Out

Background: Sildenafil, a selective phosphodiesterase -5 (PDE-5) inhibitor increases cyclic guanosine monophosphate (cGMP) and amplifies many biological actions of nitric oxide (NO) which is an important mediator of gastric mucosal defense ; was evaluated in this study using different doses for its cytoprotective effect on gastric mucosal damage induced by indomethacin . We also evaluated the effect of this drug on NO production, Prostaglandin E2 (PGE2) synthesis, Myeloperoxidase (MPO) activity, and Interlukin-4 (IL-4) expression.
Methods: The study was performed between April and July 2008 in the Department of Pharmacology / College of Medicine /Baghdad University .It was conducted on 80 adult male albin

Background: Breast cancer is the most common malignant tumor in women worldwide. In Iraq, there is a tendency for this disease to be diagnosed in younger ages, at advanced stages with a prevalence of more aggressive tumor behavior.
Patients and Methods: The study included a total of 216 women with breast lumps and proven breast cancer who visited the Main Referral Training Center for Early Detection of Breast Tumors in the Medical City Teaching Hospital in Baghdad (85 patients) and the Specialized Clinics belonging to the major hospitals of Hilla (62 patients) and Karbala (69 patients) complaining of apparent breast lumps.
Results: 31% of patients was in the age category (40-49 years), 38.4% of patients who