Steroid-resistant idiopathic nephrotic syndrome (SRNS) is a leading cause of childhood end-stage renal disease, with diverse histological features and a challenging diagnosis. SRNS has been suggested to develop due to variations in the multidrug resistance 1 (MDR1) gene, with variable results from different studies. This study explored the presence of novel variants in the MDR1 gene and evaluated their association with steroid responsiveness in Iraqi children with idiopathic nephrotic syndrome. This case-control study included children with SRNS (n=30) and steroid-sensitive nephrotic syndrome (SSNS; n=30) from the pediatric nephrology clinic in Babylon Hospital for Maternity and Pediatrics. Genomic DNA (gDNA) was extrac

Sungkai (Peronema canescens Jack) is known to have various bioactive compounds as anticancer agents. This study aims to evaluate the anticancer potential of the active compound from the ethyl acetate fraction of sungkai leaves through an experimental and computational approach. The cytotoxic activity of the ethyl acetate fraction was carried out using the MTT assay method on A549 lung cancer cells. The computational study carried out using the molecular docking method and continued with pharmacokinetic analysis of the five main compounds in the ethyl acetate fraction of sungkai leaves. The MTT assay revealed that the ethyl acetate fraction exhibited moderate cytotoxic activity against A549 lung cancer cells, with an IC₅₀

Cubosomes are lipid-based nanostructured aqueous dispersions that form through a highly organized spontaneous self-assembly process. these lipid-based dosage forms can serve as effective carriers for lipophilic, hydrophilic drugs, thereby improving the therapeutic effectiveness of the drugs., cubosomes were developed in order to investigate their efficacy as nano carriers for transdermal delivery of tizanidine (TZN), a skeletal muscle relaxant with low oral bioavailability , cubosomal vesicles were  formulated using the thin-film hydration technique, employing glyceryl monooleate (GMO) as the lipid component and poloxamer 407(p407) as the stabilizer. the vesicle characteristics were modified by varying the surfactant-to-lipid ratio. the

Systemic Lupus Erythematosus (SLE) is an immune-mediated disease with severe morbidity and tissue damage. Adherence to therapy in SLE patients remains a significant problem, and nonadherence can lead to poor disease outcomes and decreased quality of life. Self-efficacy is also a critical aspect of disease control and medication adherence. This study aims to evaluate medication adherence, quality of life, and self-efficacy among patients with SLE and their correlation with sociodemographic and clinical factors. This was cross-sectional study was conducted at Baghdad Teaching Hospital's Rheumatology Unit from November 2024 to January 2025, evaluating adherence, quality of life, and self-efficacy among SLE patients using the Compliance Ques

The in vivo antiangiogenic activity and in vitro cytotoxic effects of methanol leaf extract of Leonotis leonurus (Lamiaceae) against A2780 human ovarian cancer cells are investigated in this work. Leonotis leonurus (L. leonurus), a fellow of the Lamiaceae family and commonly Referred to as "wild dagga," or “lion’s ear” is a commercially important plant The antiangiogenic capacity was evaluated with the Avian chorioallantoic membrane (CAM) assay to reveal 100% inhibition of blood vessel growth at 500 mg/mL. Cytotoxicity was measured using the MTT assay; a dose-dependent drop in cell viability resulted from an IC50 value of 93.22 µg/mL. Phytochemical analysis investigation detects the presence of signifi

An essential chemokine called monocyte chemoattractant protein-1 (MCP-1) is in charge of initiating, controlling, and mobilizing monocytes to the sites of active severe periodontal inflammation. The purpose of the current study is to assess the serum levels of MCP-1 and protein oxidation products in chronic periodontitis patients, namely Advanced Oxidation Protein Products (AOPP), 3-Nitrotyrosine (3-NT), and Protein Carbonyl (PC). Evaluation of potential relationships between MCP-1 levels and the byproducts of protein oxidation. In the current investigation, 45 patients with severe chronic periodontitis (diseased) and 14 healthy individuals took part. Enzyme-linked immunosorbent assay was used to measure the amounts of MCP-1, AOPP, 3-NT,

Lornoxicam (LOX) is a potent nonsteroidal anti-inflammatory drug (NSAID) oxicam class; that can be used into treat ocular inflammation; when applied locally to the eye, reducing systemic side effects. However, a major challenge is its rapid lacrimal clearance.  An ion-sensitive in-situ gel for lornoxicam (LOX) was developed using gellan gum, a polymer that gel in response to calcium ions present in physiological fluids. This method allows for the local and continuous release of medication, improving therapeutic efficacy. The aim of this study was to

Oxidative stress arises when the host defensive mechanisms of anti-oxidants cannot withstand the fierce attack launched by numerous reactive oxygen and nitrogen species. This prooxidant-antioxidant imbalance can cause endocrine, cardiovascular, pulmonary, and neurological disorders. In sepsis, this imbalance promotes organ failure, including bone marrow. The aim is to evaluate the anti-oxidant effect of montelukast compared with dexamethasone against LPS-induced oxidative stress in bone marrow. For this purpose, twenty-eight male Albino mice were randomly assigned to four groups of seven per each. Group I (control) received distilled water by oral gavage once a day for a week and euthanised on the 8th day; Group II (induction) received a

    Methotrexate, a folic acid antagonist, is a chemotherapeutic agent frequently employed in treating certain forms of cancer. Nephrotoxicity caused by high-dose Methotrexate is a medical emergency due to the delayed renal excretion of Methotrexate. Chromium is a trace element found in certain foods and the environment. The primary function of chromium is to regulate glucose levels, which is used as a supplement by people with type 2 diabetes Mellitus. This study aimed to evaluate the renoprotective effect of chromium against Methotrexate-induced Nephrotoxicity in rats. Thirty-two Wistar rats were allocated into four groups and treated as Group-1 (Control group): The rat was administered distilled water orally as a vehicle f

Drug-induced acute kidney injury is a serious disorder. Oxidative stress has a key role in its initiation and progression. In this study, the possible ameliorative effect of fimasartan against methotrexate-induced nephrotoxicity was investigated in comparison with α-tocopherol in rats. Wistar rats were allocated into six groups and treated as follows: group Ӏ received water on a daily basis for 8 successive days; group ӀӀ received methotrexate (20 mg/kg) on day 1, followed by water for 7 successive days; group ӀӀӀ received fimasartan (3 mg/kg/day) for 7 successive days; group IV received α-tocopherol (1 g/kg/day) for 7 successive days; group V re

Abstract

Prescribing drugs to patients to treat ailments or reducing their morbidity may not be enough, even if the drugs were all indicated and in the right dose. Clinical pharmacists play a pivotal role in conducting information and instruction to patients and conveying feedback to treating physician when appropriate, and the final goal is in the interest of the patient.  Identification and classification of drug related problems and discussing them with the health care providers.  Prospective, interventional, clinical study for 180 hemodialysis patients, and was designed as two phases, an observational phase to identify drug related problems and classifying them according to the latest Pharmaceutical

Intestinal mucositis is referring to inflammatory or ulcerative lesions of the oral or gastrointestinal tract; one of the main reasons is treatment with cancer chemotherapy. The prodrug Irinotecan is converted by carboxylesterase to the active metabolite SN-38, conjugated by UGT enzyme to SN-38G and then deconjugated by ?-glucoronidase produced by intestinal bacterial flora to produce SN-38. Irinotecan induces intestinal mucositis and diarrhea due to increased concentration of its active metabolite (SN-38).To evaluate the protective effect of carvone, I.P injection of (75mg/kg/day) of irinotecan for 4 days to induce intestinal mucositis, carvone administered to mice orally for 6 days starting from day 1. Results showed that carvone (50mg

Solid dispersion is an attractive tool of pharmaceutical technology used to improve the physical properties of drugs. Among these properties is to enhance the solubility of the drugs.
Rebamipide is a poorly soluble drug of class IV of biopharmaceutical classification system (BCS).
Rebamipide is used as potent antiulcer, mucoprotective drug, by stimulating the generation of prostoglandine enhanced mucosal protection.
Rebamipide was formulated as a solid dispersion using different polymers such as pluronic F-127, PEG6000, PVP K30, and TPGS by using different preparation methods solvent evaporation, fusion, and kneading methods.
It was seen that rebamipide was successfully dispersed in a homogenous solid dispersion matrix by sol

Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line.

In recent decades, drug modification is no longer unusual in the pharmaceutical world as living things are evolving in response to environmental changes. A non-steroidal anti-inflammatory drug (NSAID) such as aspirin is a common over-the-counter drug that can be purchased without medical prescription. Aspirin can inhibit the synthesis of prostaglandin by blocking the cyclooxygenase (COX) which contributes to its properties such as anti-inflammatory, antipyretic, antiplatelet and etc. It is also being considered as a chemopreventive agent due to its antithrombotic actions through the COX’s inhibition. However, the prolonged use of aspirin can cause heartburn, ulceration, and gastro-toxicity in children and adults. This review article hi

  Breast cancer is the most common cancer among women over the world. To reducing reoccurrence and mortality rates, adjuvant hormonal therapy (AHT) is used for a long period. The major barrier to the effectiveness of the treatment is adherence. Adherence to medicines among patients is challenging. Patient beliefs in medications can be positively or negatively correlated to adherence. Objectives: To investigate the extent of adherence and factors affecting adherence, as well as to investigate the association between beliefs and adherence in women with breast cancer taking AHT. Method: A cross-sectional study included 124 Iraqi women with breast cancer recruited from Middle Euphrates

Background: Pain due to muscular cramp during hemodialysis is one of the most common problems experienced by patient undergoing hemodialysis, and is associated with poor outcomes of patients. The main aim of this study was to comparing the effects of lavender oil and olive oil massage on Pain due to muscular cramp during hemodialysis.

Methods: In this random clinical trial, 60 hemodialysis patients were enrolled randomly and allocated to two groups with 30 members in Lordegan and Brojen hospitals, Shahrekord, Iran. The intervention included flora massage on the lower leg muscles so that the first group received olive oil massage (10 drops) and the second group received lavender oil massage (10 dr

The effective surface area of drug particle is increased by a reduction in the particle size. Since dissolution takes place at the surface of the solute, the larger the surface area, the further rapid is the rate of drug dissolution. Ketoprofen     is class II type drug according to (Biopharmaceutics Classification System BCS) with low solubility and high permeability. The aim of this investigation was to increase the solubility and hence the dissolution rate by the preparation of ketoprofen     nanosuspension using solvent evaporation method. Materials like PVP K30, poloxamer 188, HPMC E5, HPMC E15, HPMC E50, Tween 80 were used as stabilizers in perpetration of differ

Abstract

Objective: the idea of this study to improve transdermal permeability of Methotrexate using eucalyptus oil, olive oil and peppermint oil as enhancers.
Method: eucalyptus oil (2% and 4%), peppermint oil (2% and 4%) and olive oil (2% and 4%) all used as natural enhancers to develop transdermal permeability of Methotrexate via gel formulation. The gel was subjected to many physiochemical properties tests. In-vitro release and permeability studies for the drug were done by Franz cell diffusion across synthetic membrane, kinetic model was studied via korsmeyer- peppas equation.
Result: the results demonstrate that safe, nonirritant or cause necrosis to rats' skin and stable till 60 days gel was successfully formulated.<