Background: To determine the DNA content in subfertile patients and to correlate it with seminal sperm concentration.
Design: Prospective observational study.
Setting: College of Medicine, Dept. of Physiological chemistry and Institute for embryo Research and infertility treatment-University of Baghdad.The study was conducted
through years 2004-2005.
Methods: A random sample of 61 subfertile male patients undergoing semen evaluation and aged from 20-45 years were studied. Semen samples were assessed for seminal sperm
concentration microscopically and were classified into 3 different groups according to count (million/ml).Then sperm D N A content (μg/ml) was estimated using a microchemical
spectropho

Background: uterine involution is the process by which the postpartum uterus returning to its prepregnant state by the process of autolysis. The aim of the study is to fallow the uterine involution sonographicly during the first two weeks of puerperium and clinical correlation of several puerperal conditions was sought.
Patients and methods: One hundred full term women were delivered in one of Baghdad hospital during a six month period were followed by serial sonogram during the first two weeks of the puerperal period to show the normal process of uterine regression in relation to several condition .The rate of uterine involution were shown as percentage drop in uterine volume at day (7) and day (14)&nbsp

Background: Otitis media with effusion(OME)is a common cause of deafness in children with subsequent impairment of speech development and scholastic difficulties.Treatment
remains controversial.
Aim: To study the effect of amoxicillin-clavulanate in treatment of OME
Patients and methods: A prospective study of a target sample consisting of sixty children under the age of 12 years presented with chief complaints duration for at least 6 weeks and
on examination there were bilateral red and retracted tympanic membranes without oversized adenoids and no underlying causes require surgical correction e.g cleft palate.The
patients were divided into two groups;group A which received Actifed for 4 weeks and grou

Background: Bronchogenic carcinoma is considered one of the most common malignant diseases that affects both sexes. The radiological profile of bronchogenic cancer can prove to be of great assistance in the management of this disease.
Objectives: The current study aimed to assess a radiological profile for bronchogenic carcinoma in a sample of Iraqi patients.
Methods: A cross-sectional study that comprised a total of 100 patients affected with bronchogenic cancer in Al-Imamain Al-Kadhimain Medical City, Baghdad, Iraq, from the 1^st of January to 31^st  of July 2020. Clinical characteristics, diagnostic modalities, the site of the tumor with

Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune illness. Oxidative stress such as Malondialdehyde plays a major role in the pathophysiology of RA while antioxidants such as Coenzyme Q10 play protect role against inflammation.

Objectives: The study aimed to compare serum concentrations of Coenzyme Q10 and Malondialdehyde in rheumatoid arthritis patients and healthy controls and to evaluate how different types of treatment (biologics and chemotherapy) influence serum levels of them in this disease. 

Methods: The case-control study was conducted on 88 individuals (60 had been diagnosed with rheumatoid arthritis and 28 healthy as (Controls). The pati

Background: Wilms' tumor and Neuroblastoma are common pediatric malignancies, with biochemical markers like plasma metanephrines and serum lactate dehydrogenase (LDH) being studied for diagnostic and prognostic values. Metanephrine, a catecholamine metabolite, is elevated in Neuroblastoma due to tumor secretion. Elevated LDH levels may correlate with tumor burden and indirectly indicate disease activity.
Objectives: To evaluate plasma metanephrine and lactate dehydrogenase as biomarkers in Neuroblastoma and Wilms tumor in pediatric patients.
Methods: The study was conducted between February and December 2024, in the Children Welfare Teaching Hospital, Medical C

Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrinology disorder affecting women in the years of reproduction. Malondialdehyde (MDA) is a result of polyunsaturated fatty acid peroxidation and is widely utilized as a trustworthy indicator of peroxidation of lipids and oxidative damage. Conversely, Vitamin D deficiency is a global issue affecting around one billion individuals. 25-hydroxyvitamin D₃ is linked to multiple metabolic processes and reproduction facets of women with PCOS and thus may contribute to the PCOS pathophysiology.
Objectives: To measure and compare serum malondialdehyde levels and 25-hydroxyvitamin D₃ concentrations between women with polycystic ovary syndrom

Background: The prevalence of multidrug-resistant bacteria has demonstrated a need to develop and use alternative antimicrobial agents. There has been a growing interest in medicinal plants and herbs and their extracts.
Objective: To identify the antibacterial and anti-biofilm activity of aqueous and alcoholic extracts of the Fenugreek (Trigonella foenum-graecum L.) seed against multidrug-resistant clinical bacterial isolates (Gram-positive Staphylococcus aureus and Gram-negative Acinetobacter baumannii).
Methods: Aqueous and alcoholic extracts were prepared from the seeds of the Fenugreek (Trigonella foenum-graecum L.) plant. A gas chromatog

Abstract:

Background: The alteration of bowel habits, bleeding per-rectum and anemia were common features in both groups in this study, but in young patients there was a delay of 6 months between the presenting symptoms and the definitive diagnosis because the disease was not suspected and investigated in them. The most common site for the tumors in young patients was the rectum and in patients above the age of 40 years was the Sigmoid.

The pathological finding showed that classification of the colorectal tumors in young patients appear moderately to poorly differentiated adenocarcinoma , this indicate a more malignant course of the disease in young patients.

This study sen

خلفية: قصور الغدة الدرقية دون السريري (SCTD) هو الأكثر شيوعا في مرحلة مبكرة من الغدة الدرقية. على الرغم من أن الشرط قد حل أو لم تتغير، في غضون بضع سنوات في بعض المرضى، قد الغدة الدرقية علني تطوير، مع انخفاض مستويات T4 الحرة، فضلا عن تحفيز الغدة الدرقية التي أثيرت هرمون (TSH) مستوى. في الخلل في الغدة الدرقية العامة هي حالة تعرف للحد من احتمالات الحمل وتؤثر سلبا على نتيجة الحمل. كما فحص لأمراض الغدة الدرقي

Background: lung function is closely related to anthropometric variables. Anegative relationship between different adiposity markers and lung function has been well established.

الخلفية :امتداد الذراعين هو اقرب قياس فسلجي للطول.زيادة نسبة الطول الى امتدادالذراعين,التي قد تعني احتمال نقص الطول نتيجة للتقدم في السن ,والذي قد ينتج عن وهن العضام المؤدي الى تهشم الفقرات,او اسباب اخرى.مما قد يكون له علاقة بوضائف الرئة.

الطرائق: المشاركين الذين راجعوا مختبر فحص وضائف الرئة في العيادة الاستشارية لمستشفى بغداد التعليمي للفترة من1/11/2009ولغاية31/1

Background: Sepsis is recognized as the leading cause of neonatal mortality globally, yet its detection remains challenging due to inconclusive signs and symptoms.
Objective: This study aimed to examine the variations in complete blood count (CBC), D-dimer, ferritin, interleukin-10, urea, and electrolyte levels among neonates with sepsis compared to healthy newborns and to identify and characterize the associated symptoms and risk factors.
Methods: An observational study was conducted at the Children's Welfare Teaching Hospital in Baghdad during the period from first of September 2023 to first of March 2024, the research involved a total of 187

Background: Between 0.3% and 2% of pregnant women experience hyperemesis gravidarum. It is recognized by persistent and unexplained vomiting and dehydration, and the diagnosis is confirmed by significant loss of weight, usually more than 5% of the pre-pregnancy weight. Tumor necrosis factor-α is a multipotent cytokine that affects a vast array of cells. It is now well accepted that the tumor necrosis factor-α is crucial in the very early stages of pregnancy.

Objectives: To assess the relationship between the tumor necrosis factor-α and hyperemesis gravidarum.

Methods: This case-control study was carried out at the Baghdad Teaching Hospital, Obstetrics and Gynecology Depa

Background: Infertility is the inability to conceive after one year of unprotected intercourse, with male factors accounting for about 50% of cases. Anti-Müllerian hormone (AMH), a glycoprotein belonging to the Transforming growth factor beta family, is secreted from Sertoli cells and plays a key role in male sexual differentiation.
Objectives: To examine the potential role of Anti-Müllerian Hormone in differentiating the subtypes of male infertility.
Methods: This case-control study was done at the Infertility Center of Al-Batool Teaching Hospital in Diyala Governorate, Iraq, by the Department of Biochemistry / College of Medicine / University of Baghdad between April 2024 a

Background: Extensively drug-resistant Klebsiella pneumoniae (K. pneumoniae) is a significant problem currently due to the increasing prevalence of this pathogen.
Objectives: To underscore the growing threat of antibiotic-resistant K. pneumoniae by investigating the prevalence of class 1 integrons among selected multidrug-resistant (MDR) clinical isolates, with the goal of emphasizing the need for strengthened surveillance and targeted antimicrobial strategies.
Methods: Seventy-four K. pneumoniae isolates have been identified out of 200 clinical samples from different clinical sources (urine, burns, blood, sputum, wounds). Isolates w

Background: Urinary tract infections are one of the most common bacterial infections, caused mainly by Escherichia coli. Uropathogenic Escherichia coli (UPEC) possess virulence factors that can worsen infections, partly regulated by the BarA/UvrY two-component system, which controls genes associated with adhesion, motility, and biofilm formation through small RNAs and carbon metabolism regulators.

Objectives: To determine the pathogenicity and some genotype features of Escherichia coli from urine specimens collected from young women patients and assess their antibiotic resistance.

Methods: Between September and November 2024, 20

Background: Breast cancer is a leading malignancy in women, shaped by genetic and environmental factors. Resistin, a potential chemotherapy target, may contribute to chemoresistance when mutated. This study applies computational methods to analyze how single-nucleotide polymorphisms alter resistin’s structure and function, potentially reducing its chemotherapy sensitivity.

Methods:  A total of 105 fresh blood samples were collected from patients recruited from the Oncology Teaching Hospital, Medical City, Baghdad, Iraq. between March-2020 and September-2023. Samples were classified into 3 groups of 35 samples each: control, benign and patients. DNA extraction, PCR, Sanger sequencing and computa

Background: Vitamin D deficiency is a risk factor for neuropsychiatric disorders and autoimmune diseases.
Objectives: This study aimed to investigate the relationship between vitamin D and the pathogenesis of primary hypothyroidism.
Methods: A case-control study was conducted at the Department of Biochemistry, College of Medicine, University of Baghdad, and Endocrinology and Diabetes Clinic. The study involved 81 patients aged 29-62 years, with 24 newly diagnosed hypothyroidism, 33 had established hypothyroidism, and 24 had subclinical hypothyroidism. The control group consisted of 40 healthy individuals aged 29-62 years. The study used the MAGLUMI® 800 analyzer Chemiluminesce

Background: Cell-cycle-regulating proteins, including cyclin-dependent kinase inhibitor 1B p27^kip1_, have been researched in different malignancies, including thyroid carcinoma, and their association with tumor aggressiveness and recurrence has been examined in many tumors.

Objective: This research aimed to examine the clinicopathological relevance of reduced cyclin-dependent kinase inhibitor 1B p27^kip1 expression in papillary thyroid carcinoma and its association with the clinicopathological parameters indicative of papillary thyroid carcinoma aggressiveness. 

Methods: Formalin-fixed, paraffin-e

Background: Axial spondyloarthritis is a chronic inflammatory disorder driven by tumor necrosis factor alpha and the interleukin-23/interleukin-17 pathway. Tumor necrosis factor alpha inhibitors such as infliximab improve outcomes, but responses vary, suggesting genetic influences; vitamin D receptor polymorphisms—particularly BsmI ( rs1544410) may modulate disease activity and therapeutic response.
Objectives: This study aimed to investigate the association between the VDR BsmI polymorphism and disease activity, as well as infliximab treatment response in patients with Axial spondyloarthritis.
Methods: A cross-sectional study was conducted on 150 AxSpA patients (108 males, 42 females) receiv

Background: Infertility is a global issue that not only affects individuals but also impacts society as a whole. Kisspeptin has emerged as a key player in the understanding of certain facets of infertility. However, research on the role of kisspeptin in fertility, particularly in assisted reproductive treatment, remains limited.
Objectives: To investigate the potential association between follicular fluid kisspeptin levels and various reproductive parameters, including the number and maturity of oocytes, fertilization rate, pregnancy detection, anti-Müllerian hormone levels, and the age of females.
Methods: Sixty infertile couples with an age range of 20 – 40 years participa

Background: Substance abuse can be defined briefly as the excessive and continuous consumption of psychoactive substances without medical supervision, leading to dependence and adverse health consequences. Substance abuse is an escalating and surging public health challenge in Iraq.

Objectives: To assess the frequency of substance abuse among a large group of senior undergraduate medical students and to identify the associated factors.

Methods: A convenience sample of 388 senior medical students from the College of Medicine/ University of Baghdad during April 2023 took part in this study. Itemployed a modified electronic version of the Drug Addiction Survey Questionnaire (D

Background: To study prevalence and method of diagnosis of acute rubella Infection during early pregnancy in Iraq.
Patients and Methods: Clinical signs and symptoms of acute rubella infection were looked for in (170) pregnant women looked before (12) weeks of gestation .Serial rubella specific IgG and IgM serological testing was done in these (170) women before (12) weeks of pregnancy, after (3) weeks, and again at (18-20) weeks of gestation.
Results: Three woman had clinical signs and symptoms of rubella infection from (26) woman were IgM positive at (9) weeks of pregnancy; (94) were IgG +ve but IgM –ve initially and also on repeat sampling after (3) weeks; while (50) women were nonimmune (IgG and I

Back ground: A urinary tract infection is one of the most common diseases occurring from neonate up to geriatric age groups
Patients and Methods: A total of (100) Midstream urine (MSU) samples were collected from patients having signs and symptoms of Lower urinary tract infection. These patients were attending Urology Clinic, Ramadi General Hospital.
Result: Culturing of (100) MSU samples on MacConky and blood agar resulted in (5) types of bacteria which included: Escherichia coli (46%) and it was found the most frequent bacteria causing LUTI. This is followed by Klebsiella pneumonia (23%), Pseudomonas aeruginosa (13%), Proteus mirabilis (10%) and Staphylococcus epidermidis (8%).
Conclusion: Out of

Background: - Carcinoma of the lung has became the most common type of cancer since 1985 & the most common cause of cancer death in both males & females.
Aim of study: - To assess the diagnostic accuracy of bronchial wash cytology & application of immunocytochemical methods, using two tumor markers (low molecular weight cytokeratin & epithelial membrane antigen) for more accurate & precise diagnosis of lung tumors.
Patients, materials and methods: - Fifty fifes suspected lung cancer cases according to their clinicoradiological examinations were included in this study.
Bronchial wash cytology was performed for all the 55 patients. Smears were stained by conventional cytological stain i

Modern international connectivity makes international cooperation essential for medical progress specifically in specialised medicine areas like haematology and oncology. Healthcare problems become more manageable when countries unite their expert knowledge with resources and creative solutions to achieve better patient results worldwide. The University of Baghdad should establish partnerships with UK healthcare organisations to address national healthcare deficiencies as they create mutual educational programs.

The systematic collaboration between UK and Iraqi healthcare institutions shows potential to transform blood-related care services. This research illustrates that multidisciplinary teams (MDTs) as well as direct partnershi

Background: The alveolar process, also called the alveolar bone, is a thickened ridge that contains the tooth sockets (dental alveoli) on the jaw bones that hold the teeth. After tooth extraction, several changes can occur in the alveolar process that may prevent or delay prosthodontic or other dental treatments. Recently, the Bovine-bone graft has been proposed to be applied in fresh extraction sockets to minimize the reduction in ridge volume. In recent experimental studies, Royal jelly has been shown to have antibacterial, antioxidant, antitumor, and anti-inflammatory properties, resulting in vascular dilatation and increased cell proliferation and differentiation.

Objective: To evaluate the ef

Background: Coronary artery disease is a leading cause of death worldwide. Troponin is released into blood from patients with reversible myocardial ischemia. Stromelysin-2 is also involved in the development and progression of atherosclerosis by tissue remodeling and degradation of extracellular matrix proteins.
Objectives: To investigate the role of serum high-sensitive cardiac troponin I (hs-cTn I) and Stromelysin-2 (Str-2) in the diagnosis and determination of the severity of coronary artery obstruction.
Methods: This cross-sectional study was conducted on 125 subjects undergoing coronary angiography for suspicion of coronary artery disease in Baghdad Teaching Hospital/ Medi