The results of the current study showed that the liver of H. javanicus appeared as large lobulated organ divided into six distinct lobes, that filled the cranial region and little extended to the middle region of abdominal cavity. On the other hand, liver of S. carolinensis laid against the diaphragm, occupied the cranial region of the abdominal cavity and consisted of five lobes. The liver is surrounded with a thin capsule of dense regular collagenous connective tissue and few numbers of smooth muscles fibers can be seen in the capsule that covered the squirrel liver. The liver parenchyma divided into a large number of interconnected hepatic lobules marked only by the abundant amount of connective tissue bordered the triads, and within these lobules, polyhedral shaped hepatocytes are arranged as cords of one cell thick. The liver cords are enclosed by irregular hepatic sinusoids and ordered in radial fashion around the central vein. The portal areas are consisting of branches of the hepatic portal vein and hepatic artery as well as (1-4) branches of the bile duct that appear in different sizes. Cuboidal epithelium type is lined the small branches of these ducts, while the large sized of them is lined by columnar epithelium type, in which the goblet cells appeared to be more frequently and clearer in H. javanicus than S. carolinesis. In weasel, sometimes the triad structures of large and small sized portal areas are embedded together in one abundant mass of connective tissue.