استشعار النصاب (Quorum sensing, QS) هو آلية معروفة تستخدمها جراثيم عديدة للسيطرة على عوامل الضراوة الهامة من خلال الإنتاج والاستجابة اللاحقة ل .)N-acylhomoserine (AHLs جرى تسجيل تثبيط استشعار النصاب (QSI) ، الذي يستهدف الإشارات المعتمدة على AHL، كاستراتيجية للسيطرة على الأمراضية الجرثومية. وبالتالي، تهدف هذه الدراسة إلى البحث عن قدرة جرثومة الزائفة الزنجارية كمؤشر للفحص السريع عن QSI المحتمل المتسبب عن المستخلصات النباتية على أساس تثبيط الصبغة. استخدمت أربع مستخلصات نباتية كحولية بضمنها: براعم زهور القرنفل المجففة ( Syzygium aromaticum L)، لحاء القرفة (Cinnamomum cassia L)، أوراق المورينجا (Moringa oleifera Lam)، والقطب (Tribulus terrestris L) وجرى مقارنة قابيلتها على التثبيط QSI)) مع الفيورانون. استخدمت طريقة الانتشار في حفر الهلام، إذ جري تلقيح عزلة الزائفة الزنجارية على وسط الهلام الخاص بـها الذي احتوى على حفر بحجم 8 ملم لتحميل تراكيز مختلفة من المستخلصات النباتية فضلا عن الفيورانون أو محلول الفوسفات الداريء (سيطرة سالبة). أظهرت النتائج نجاح الفيورانون في تثبيط صبغة البايوسيانين للزوائف الزنجارية دون التداخل مع النمو الجرثومي، وهذا يؤكد قدرة هذه العزلة الجرثومية كمؤشر فعال يستدل من خلاله على وجود QS. الأهم من ذلك، سبب مستخلص القرنفل بتراكيز مختلفة في تثبيط تام لصبغة البايوسيانين مع تأثير ضئيل على النمو الجرثومي. عند استخدام القرفة، أظهرت التراكيز العالية فقط تثبي ًطا واض ًحا لصبغة العزلة المستخدمة. تسببت المورينغا أي ًضا في درجة معينة من تثبيط الصبغة ولكن بتراكيز عالية فقط. وعلى العكس من ذلك، لم يؤثر القطب على إنتاج البيوسيانين ولا على الحيوية الجرثومية. يستنتج من هذه الدراسة نجاح عزلة الزائفة الزنجارية المنتجة للبايوسيانين في فحص مثبطات QS. توصي هذه الدراسة البسيطة باستخدام مثل هذه العزلة ككاشف عن QSI دون الاعتماد على استيراد سلالات معينة من جراثيم Chromobacterium violaceum أو Pseudomonas aureofaciens أو Agrobacterium tumefaciens.
Background: The prevalence of spinal cord lesions is high in multiple sclerosis particularly in the cervical cord, and their detection can assist in both the diagnosis and follow-up of the patients. For spinal multiple sclerosis, MRI is considered the first line investigation.
Objective: To evaluate the value of sagittal 1.5 Tesla proton density-fast spin echo (PD-FSE) MRI in the detecting and increasing conspicuity of multiple sclerosis lesions in cervical cord in comparison with sagittal T2 fast spin-echo (T2-FSE) MRI.
Patients and Methods: A cross sectional study carried out from 3rd of January 2017 to 1st of January 2018 in the MRI department of
... Show MoreSamuel Beckett’s Happy Days (1961) clearly portrays a lack of communication among the characters of the play which refers to the condition of modern man. This failure of communication led Samuel Beckett to use a lot of pauses and silences in all plays written instead of using words. To express the bewilderment of the modern man during the 20th century, Beckett adopts the use of no language strategy in the dramatic works. After World War II, people were without hope, religion, food, jobs, homes, or even countries. Beckett gave them a voice. He used a dramatic language out of everyday things, in which silence was part of the syntax as a poetic repetition. Language is no more important to the modern man; instead, he us
... Show MoreBackground: Thiopurines are essential medications in Acute Lymphoblastic Leukemia (ALL) treatment protocols as anti-cancer agents since long time; however, their use might result in unexpected toxicities in ALL children due to the low thiopurine S-methyltransferase (TPMT) activity, a major enzyme involved in 6- mercaptopurine metabolism, which strongly correlates to the genetic polymorphism of the TPMT gene in those patients.
Objective: To identify the most common TPMT polymorphisms in children with ALL and its frequencies.
Methods: A cross sectional study enrolling eighty-one ALL children receiving mercaptopurine drug during their maintenance course of treatment accordin
... Show MoreObjectives: the study aims to assess nurses' practices toward chemotherapy-induced peripheral neuropathy (CIPN) for children at the hematology center, and to determine the effectiveness of the health education program on nurses' practices toward CIPN, and to find out the relationships between the effectiveness of Health education program and demographic characteristics of nurses.
Methodology: Use quasi-experimental design in the study (a design that divides the sample into two groups, a study group and a control group, with data collection in three stages). This study was conducted at a hematology center in Baghdad city for the period (from December 16th, 2019 to 8th May 202
... Show MoreThis research deals with the role of quantitative (indirect) tools of monetary policy that used by the Central Bank of Iraq in order to control and manage the size of the money supply that intermediate goal through which monetary policy is able to achieve its final goals, foremost among which is to reduce inflation and raise the value of the local currency in front of foreign currency rates. The research is based on a major hypothesis stating that quantitative tools have a direct and strong influence on the money supply, especially under the circumstances of the shift towards a market economy. There has been a branching relationship with this statistically significant relationship between the money supply and the quantitative tools used
... Show MoreOrganophosphorus insecticide and growth regulator namely Ethephon (2-chloroethylphosphonic acid) are widely used as a ripening process accelerator and a cultivation duration inhibitor. Pomegranate extract (PPE) has recently been taken into consideration due to its pharmacological effects especially those associated with renal diseases. Thus, this study aims to investigate the possible protective effect of PPE against ethephon-induced nephrotoxicity in rats. In this study four groups of adult male rats were divided into control group, PPE 400 mg/kg group, Ethephon 250 mg/kg group, and finally, PPE + Ethephon group (treated with the same dose of PPE group and Ethephon group). In the current study, kidney function parameters (KIM-1, creatin
... Show MoreHepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. Therefore, it is critical for researchers to understand molecular biology in greater depth. In several diseases including cancer, abnormal miRNA expression has been linked to apoptosis, proliferation, differentiation, and metastasis. Many miRNAs have been studied in relation to cancer, including miR-122, miR-223, and others. Hepatitis B and C viruses are the most important global risk factors for HCC. This study is intended to test whether serum miRNAs serve as a potential biomarker for both HCC and viral infections HBV and C. The expression of miRNA in 64 serum samples was analyzed by RT-qPCR. Compared to healthy volunteers, HCC patients' sera expre
... Show MoreBackground: Venous thromboembolic disease (VTED) is a well known complication that occur following total knee arthroplasty (T.K.A). One of the (VTED) forms is asymptomatic deep venous thrombosis with an incidence has been estimated to be up to ³ 20% in patients undergone primary T.K.A , despite routine treatment with heparin postoperatively.
Objectives : is to assess the prevalence of post-operative asymptomatic D.V.T among patients receiving two different thromboprophylactic drugs after T.K.A.
Patients and methods: 68 patients who had T.K.A were randomly divided for the purpose of post-operative thromboprophylaxis into two groups , group [ A ] (control group) consisted
... Show MoreBackground: Ultrasound guided fine needle aspiration (FNA) is a quick nonmorbid method of staging disease in the axilla,Color doppler ultrasound is used to differentiate benign lymph node from node that bears metastasis.
Objective: To evaluate the utility of ultrasound guided (FNA) of the axillary L.N depending on the size of the primary tumor and the appearance of the lymph node by ultrasound , and to document the difference in color Doppler flow features between benign and malignant lymph node in women with primary breast cancer.
Patients and methods: The total number of the patient in the study is (60). Data were collected about tumor size, lymph node appearance and color-power Doppler sonography compared to the result of ultras
The study aimed to examine the impact of audit committee characteristics on the practices of intellectual capital disclosure in the annual reports of Bank and Insurance companies listed on Palestine Exchange, through performing content analysis of the annual reports for the study sample which totaled thirteen companies, including six banks and seven insurance companies. To achieve the study objectives, the study employed a content analysis approach in order to analyze the content of the intellectual capital disclosure practice, in addition, the study used cross-sectional with longitudinal data for time series for a period of time between 2014-2019. The empirical results indicated that financial expertise and the number of meeting
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