Total dissolved solids are at the top of the parameters list of water quality that requires investigations for planning and management, especially for irrigation and drinking purposes. If the quality of water is sufficiently predictable, then appropriate management is possible. In the current study, Multiple Linear Regression (MLR) and Artificial Neural Network (ANN) models were used as indicators of water quality and for the prediction of Total Dissolved Solids (TDS) along the Tigris River, in Baghdad city. To build these models five water parameters were selected from the intakes of four water treatment plants on the Tigris River, for the period between 2013 and 2017. The selected water parameters were Total Dissolved Solids (TDS), Total Hardness (TH), Electrical Conductivity (EC), sulfate (SO4), and Total Solids (TS). The results showed that the Tigris river water quality was appropriate for drinking according to the World Health Organization (WHO) and Iraqi standard specifications for drinking water, the performances of the ANN and MLR models were evaluated by utilizing the coefficient of determination (R2). The results showed that the computed values of R2 for MLR and ANN were 0.797, 0.813, respectively; and the sensitivity analysis indicated that TS and TH had the high effects for predicting TDS.