An experimental and numerical investigation of the effect of using two types of nanofluids with suspending of (Al2O3 and CuO) nanoparticles in deionized water with a volume fraction of (0.1% vol.), in addition to use three types of fin plate configurations of (smooth, perforated, and dimple plate) to study the heat transfer enhancement characteristics of commercial fin plate heat sink for cooling computer processing unit. All experimental tests under simulated conditions by using heat flux heater element with input power range of (5, 16, 35, 70, and 100 W). The experimental parameters calculated are such as water and nanofluid as coolant with Reynolds number of (7000, 8000, 9400 and 11300); the air is blown in the inlet duct across the heat sink with Reynolds number of (10500, 12300, 14200 and 16000). The distance fin-to-fin is kept constant at (2.00 mm), and the channel employed in this work has a square cross-section of (7 cm) inside. It was observed that the average effectiveness and Nusselt number of the nanofluids are higher compared with those of using conventional liquid cooling systems. However, the perforated fin plate showed higher air heat dissipation than the other configuration plate fin employed in this study. The experimental results were supported by numerical results which gave a good indication to heat transfer enhancement in studied ranges.