This study employs an integrated research model to examine the syntax properties of the historic urban network in older Baghdad, explaining how spatial configurations affect urban functions and land use. The relationship between the street network and land use pattern is again the focus for architects and urban planners trying to revitalize historic urban cores. In this research, a multi-method approach is used, incorporating GIS, space syntax analysis, statistical correlations, and site observations, to systematically analyze the syntactic properties of the street network in Old Rusafa. The examination was conducted within a 400m radius of Old Rusafa's historic urban fabric to analyze the syntactic processes that govern the city’s functionality and accessibility despite the multiple morphological changes that have happened in the area. Results show a strong correlation between street network and land use in Old Rusafa, commercial areas positive (ρ=0.175, p<0.01) and residential areas negative (ρ=-0.234, p<0.01). High choice values also correlate with commercial activity (ρ=0.160, p<0.01), so spatial accessibility plays a big role in shaping urban functions and land use. There is a lot to learn from this in other historical urban situations to compare and apply urban design principles based on syntactic properties. Comparative research like this can help architects and urban planners understand the universality of space syntax in urban design.