The worldwide construction industry has recognized the necessity for lightweight building materials that are flexible, high-performance, and environmentally friendly. In response to this need, lightweight foamed concrete (LFC) is being proposed. In concrete, nanoparticles are utilized for their beneficial effects, such as their small particle size and high reactivity, which improve the strength of concrete. In this study, foam concrete block waste was used as a partial substitute for cement in the manufacture of foamed concrete. The experimental program was done by preparing finally ground foam concrete wastes by using specific machines to produce particles similar to cement particles. The replacement ratios are (0, 10, 20, and 30) % by weight of cement and the TiO2 ratio was 0.5% for all mixes. The mechanical properties, including compressive and tensile splitting strength, were examined at 7 and 28 days. Results indicate that FCBW decreases mechanical and durability properties due to increased porosity and reduced cement content at higher replacement levels. The findings show that adding more FCBW lowers compressive and tensile strengths, while mixes M1 and M2 keep strength ratios near the reference mix. However, a mix containing 10% FCBW and 0.5% nano-TiO2 offers a promising mechanical performance.