The antimicrobial activity of the alcoholic extract of the Cressa cretica plant was evaluated against six Gram-positive and Gram- negative bacteria: Bacillus cereus, Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Klebsiella aerogenes using well diffusion method. The maximum antibacterial activity was achieved with the concentration of 500 mg/ml alcoholic extract of Cressa cretica . E. coli was showed the highest inhibition of the growth followed by Klebsiella aerogenes and Staphylococcus aureus, while the other concentrations of (250,125) mg/ml did not show any inhibiting effect for all kinds of the bacterial used. Moreover, the preliminary phytochemical analysis revealed that there were a present of tannins, saponins, terpenoides and flavonoids using different solvents.