This study examined the effect of replacing local feed mixture with protein concentrate in broiler feed on production, histological, and microbial characteristics. The study was conducted on 200 one-day-old broiler chicks of Ross 308, randomly divided into four treatments, 50 chicks per treatment, with five replicates and 10 chicks per replicate. The control treatment (T1) was fed 5% protein concentrate, while the protein concentrate in the other treatments (T4, T3, T2) was replaced with protein concentrate in varying proportions (2%, 2.5%, 3%). The feed mixture contains several components, including the carrier materials, which are potato peels at a rate of 33%, and active materials, which are a group of amino acids represented by (methionine, lysine and threonine) and a group of herbs represented by (turmeric, cumin, anise, coriander, cinnamon) in addition to a biological enzyme, a biological antitoxin and probiotic in addition to a mixture of vitamins, minerals and oil. The results showed no significant differences in body weight, feed consumption, weight gain, or feed conversion ratio at the age of (0-39 days). As for the fourth treatment, it led to a significant decrease in the number of bacteria and an increase in villi length. The study concluded that it is possible to replace 3% local feed with 5% imported protein concentrate without negative effects on broiler chickens.