This study compared the effectiveness of synthetic hormone Ovaprim and natural Carp pituitary extract (CPE) in inducing spawning in common Carp. A total of 12 females and 24 males were divided into two groups. The first group received a single dose of Ovaprim (0.5 ml/kg for females, 0.25 ml/kg for males). The second group received CPE: females were given two injections (10% + 90%, total 4 mg/kg), and males one dose (2 mg/kg). Fertilization was done by dry method 8–10 hours after injection. Hatching occurred after 46 hours in Ovaprim group and 42 hours in CPE group. Statistical analysis showed significantly better results for Ovaprim in ovulation rate (100% vs. 83.33%), fertilization rate (96.5% vs. 76%), and hatching rate (97% vs. 63.21%). Latency period was longer with Ovaprim (12h 38m vs. 10h 21m).