This study aimed to evaluate the effectiveness of some plant extracts of yerba mate Ilex paraguariensis and Cinnamonum cassia against the pathogen Vairimorpha (Nosema) ceranae in the digestive system of workers of the global honey bee Apis mellifera L. at different concentrations, and showed The results of the laboratory study showed that the alcoholic extract and powders of mate and cinnamon plants at concentrations of 1, 2, and 3% were efficient concentrations and had no side effects on bees. The alcoholic extract of mate at a concentration of 3% was more efficient than the rest of the other concentrations and reached 2070, 1980, 1730, 1390,1080 and 70 x 10³ spores / ml respectively with a reduction rate of 97%, The alcoholic cinnamon extract, at a concentration of 3%, was more efficient than the other concentrations, reaching 2600, 2350, 2260, 2190, 1750, 1390, and 1140 x 10³ spores/ml respectively with a reduction rate of 56% after 1,3,7,14,21, and 28 days respectively. Yerba mate powder at a concentration of 3% was more efficient than the rest of the other concentrations, which reached 2470, 2240, 2080, 1750, 1460, and 1020 x 10³ spores / ml respectively with a reduction rate of 61%, and cinnamon powder at a concentration of 3% reached 2530, 2440, 2280, 2050, 1920, and 1810 x 10³ spores/ml respectively with a reduction of 33% after 1,3,7,14,21, and 28 days respectively.