This experiment was carried out at one orchards grapes in Diyala, during two seasons 2022-2023 on grape, to study the effect of adding bacterial and fungal biofertilizers, vermicompost fertilizer, and foliar applied mineral fertilizer NPK on growth and production characteristics on cv. Helwani, the experiment was carried out a randomized complete block design within split plot with three factors and three replicates, using of 72 trees. The first factor included the addition biofertilizers which included: without inoculation (M0), inoculation with 400 g of fungi (M1).Inoculation with 200 g of bacterial (M2) and inoculation with both fungi and bacteria (M3). The second factor included the addition of organic fertilizer with three treatments, without addition (N0), adding 5 kg/ tree^-1 (N1) and adding 7 kg/tree^-1 (N2), and the third factor included foliar applied mineral fertilizer NPK as two treatment, without spraying (F0) and Spraying with 2.5 ml L^-1 of fertilizer (F1), four foliar applications were applied at 30 day intervals when leaves reached full expansion, results showed significant impact by the triple interaction treatment M3N2F1 on vegetative growth traits such as leaf area, chlorophyll, dry weight, mature canes length and immature canes length, by producing 92.48, 109.67cm², 279.26, 312.60 (mg.100g^-1f w), 48.12, 53.23% and 208.60cm, 214.53 cm, 28.81, 25.88 cm for two seasons Sequentially, the highest percentage of N, P and K in leaves in the mentioned treatment for both seasons.