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Comparison Effect Of Vitamin C Vaginal Tablet Versus Oral Metronidazole For Treatment Of Bacterial Vaginosis

Back ground: Bcaterial vaginosis is an important gynecological problem, during reproductive age group with high relapse rate ,it is associated with high vaginal PH, vaginal vitamin C recently tried to decreased vaginal PH and treat bacterial vaginosis.
Patients & Methods: One hundred and one women with Bacterial vaginosis their age range from 18-40 years enrolled in this study, the Diagnosis is confirmed by at least 3out of 4 of (Amsel criteria) which include a thin homogenous vaginal discharge, vaginal PH of ≥4.7, a characteristic ''amine odour'' release when alkali (lo% KOH) is added to a specimen of vaginal fluid, and at least 20% of epithelial cells having the appearance of clue cell in a wet mount of vaginal fluid or on gram stain . All women were randomly assigned to receive either 250mg vitamin C vaginal table at bed time for 6days (51patients) or oral metronidazole 500mg twice daily for 7days (50 patients) the patients were evaluated at two follow up visit 1st after treatment completed and 2nd one week later. Therapeutic success was defined as the presence of less than 3 Amsel criteria.
Results: Regarding the infection with bacterial vaginosis no significant difference between two groups, (15.9%) of patients still infected with bacterial vaginosis at 1st follow up visit in (vagi-C) treated group. Compare to 26.7% of metronidazole group P=0.5, this confirmed at 2nd follow up visit P=0.1. Regarding vaginal PH there is significant reduction of vaginal PH in both groups at end of treatment P=0.0032 in Vagi-C, and P=0.0001 in metronidazole treated group.
Conclusion: Vitamin C vaginal table 250mg has effective as oral metronidazole for treatment of bacterial vaginosis.

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Publication Date
Thu Apr 28 2022
Journal Name
Iraqi Journal Of Science
Molecular and Bacteriological Detection of Some Bacterial Vaginosis Associate Bacteria in Women

Bacterial vaginosis (BV) is one of the most common genital infections among women in the childbearing age. Many novel, fastidious and uncultivated bacterial species are related with BV. These are called bacterial vaginosis associated bacteria (BVAB), present in trace amount and have a significant role in the infection. A total of 80 vaginal swabs were obtained from 80 pregnant and non-pregnant women. Samples were collected from different hospitals in Baghdad city and Al-Kut city.
Clinically, 60 sample among 80 were gave positive results depending on Nugent score and Amsel criteria ,the Bacteriologicall test showed the percentages of gram negative bacteria (E.coli ,K.pneumoniae, P.mirabilis, Ps.aeruginosaand A. baumanniiwere) were (38.

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Publication Date
Tue Apr 01 2008
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Bacterial Vaginosis and Premature Uterine Contraction among Women in Ramadi City

Background :
To study the incidence of premature uterine contraction (PUC) with bacterial vaginosis (BV) in Ramadi city and to correlate the incidence of (PUC) with severity
(grades of BV).
Patients and Methods:
A prospective study was performed involving 250 women who consecutively attended Gynecological ward in Maternity and Child Hospital. 150 women were
control groups (without uterine contraction), and 100 women were regarded as patients group (with uterine contraction) at 28-34 weeks of gestation. BV was
diagnosed on the basis of four diagnostic criteria; vaginal pH>4.7, homogenous vaginal discharge, a positive Whiff test, and the presence of clue cells.
Results:
A total of 250 high vag

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Publication Date
Tue Oct 01 2024
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Comparison of ََQuality of Life and Treatment Satisfaction among Sample of Iraqi Patients Using Anticoagulant Therapy (Warfarin or Non-Vitamin K Antagonist Oral Anticoagulants)

Background: Oral anticoagulation medication, warfarin and non-vitamin k antagonist oral anticoagulants  (NOAC) may require long term use which may affect patients’ satisfaction with their treatment and their quality of life (QOL). Objective: To compare the quality of life and treatment satisfaction among groups of patients using different anticoagulant therapies (warfarin and NOAC). Patients and methods: A cross-sectional study was performed at Ibn Al-Bitar Hospital for cardiac surgery in Baghdad in the period between December 2022 to May 2023. The study population included a convenient sample of patients receiving either warfarin or non-vitamin k antagonist oral anticoagulants treatment. The Arabic version of the short form 12

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Publication Date
Wed Mar 29 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Development of Modified Release Nicotine Tablet Formulation for Treatment of Ulcerative Colitis

One of the therapeutic effects of nicotine  is used as  a protective against developing ulcerative colitis . ulcerative colitis is an inflammatory disease of the bowel affecting the superficial lining mucosa in the rectum and large intestine. In this study nicotine tablets were formulated as modified release tablets targeted to the colon. All formulas were studied for drug release , effect of diluent, retardant concentration, avicel grade,and compression force, the selected formula was then further studied for drug release in 3 different pH ( coated tablets) .The kinetic study revealed acceptable shelf life  . Finally the selected formula was given to 6 patients in a pre-liminary clinical study which showed that nicotine c

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Publication Date
Thu Jan 20 2022
Journal Name
Journal Of Clinical Medicine
Comparison of the Safety and Efficacy of Laser Versus Pneumatic Intracorporeal Lithotripsy for Treatment of Bladder Stones in Children

This study aimed to compare the safety and efficacy of laser lithotripsy and pneumatic lithotripsy, the two most commonly used transurethral lithotripsy methods for treating bladder stones in children in Iraq. Between January 2013 and December 2016, 64 children with bladder stones were included in this prospective randomized study, after ethical committee approval and written consent from the children’s parents or caregivers were obtained. Patients were assigned randomly by computer software to two groups treated with either pneumatic cystolithotripsy or laser lithotripsy. A 9 Fr. semirigid ureteroscope was used to pass the lithotripter through and fragment the stone. A catheter of 8–12 Fr. was then introduced and kept in place

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Publication Date
Wed Mar 29 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Development and in vitro Evaluation of Bioadhesive Vaginal Tablet using Econazole Nitrate as a Model Drug

         In this study, a bioadhesive dosage form of eoconazole nitrate for vaginal delivery was designed using a combination of bioadhesive polymers: Carbopol 941 p and sodium carboxymethylcellulose or methylcellulose in different ratios. The bioadhesive strength was evaluated by measuring the force required to detach the tablet from sheep vaginal mucosal membrane. It was found that the bioadhesive force was directly proportional to Carbopol 941 p content in the different formulae. The formulae were tested for their swelling behavior using agar gel plate method. The results showed that formulae containing a combination of Carbopol 941 p and sodium carboxymethylcellulose had greater swelling index

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Publication Date
Tue Aug 05 2014
Journal Name
International Journal Of Pharmacy And Pharmaceutical Sciences
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Publication Date
Tue Jun 11 2019
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Preparation and In-Vitro Evaluation as an Oral Microsponge Tablet of Baclofen

The aim of the present study is to formulate floating effervescent microsponge tablet of the narrow absorption window drug, Baclofen (BFN) for controlling drug release and thereby decrease the side effect of the drug. The microsponges of BFN were prepared by non-aqueous emulsion solvent diffusion method (oil in oil emulsion method). The effects of drug: polymer ratio, stirring time and type of Eudragit polymer  on the physical characteristics of microsponges were investigated and characterized for production yield, loading efficiency, particle size, surface morphology, and in vitro drug release from microsponges. The selected microsponge formula was incorporated into the floating effervescent gastro-retentive tablet. The prepared fl

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Publication Date
Thu Jun 01 2023
Journal Name
Baghdad Science Journal
The role of Adipocytokines, Vitamin D, and C in Colorectal Cancer

Colorectal cancer is the world's 3rd most frequent malignant neoplasm and the 4th most common cancer in Iraq. Leptin and Adiponectin are two major Adipocytokines produced by adipose cells that have opposite effects on the formation of colorectal tumors. Leptin induces tumor growth and metastasis, whereas Adiponectin inhibits it. 1,25-Dihydroxyvitamin D controls and limits cancer cell proliferation, differentiation, and survival. Vitamin C deficiency, on the other hand, has been regularly detected in cancer tissues and has potent anti-cancer properties. The purpose of this study was to look at the biochemical role of circulatory Adipocytokine levels (Adiponectin and Leptin) as well as the anti-cancer potentials of Vi

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Publication Date
Sat Jan 01 2022
Journal Name
Materials Today: Proceedings
Application of levofloxacin and doxycycline in treatment of vaginal chlamydial infection

Doxycycline and levofloxacin are heterocyclic organic compounds that are now popularly used to treat some bacterial infections. In this study which was conducted on patients from a private clinic, we compared the use of two commonly used antibiotics for the treatment of diagnosed cases with vaginal chlamydial infection: levofloxacin and doxycycline. Vaginal chlamydial infection is considered to be a very common sexually transmitted infection. It may have minimal symptoms which can lead to neglect by the patient until it leads to some important complications among which is the inability to become pregnant. This indicates early diagnosis and treatment of this infection. By comparing the results of treatment we concluded that there is no much

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