Background: Cataract surgery is one of the most common surgeries, and changes in intraocular pressure might occur after cataract surgery, and some postoperative medications might affect it.

Objectives: Evaluate the effects of the non-steroidal anti-inflammatory drug bromfenac 0.09% ophthalmic solution on intraocular pressure (IOP) after phacoemulsification surgery and report any side effects of the drug.

Patient and Method: This is a prospective study done in an ophthalmic center in Iraq involving adult patients with senile or iatrogenic cataracts prepared for cataract surgery by phacoemulsification with intraocular lens (IOL) implantation and were divided into two groups: Group one: who received 0.09% bromfenac ophthalmic solution twice daily in addition to Moxifloxacin 0.5% ophthalmic drops every 6 hours and Dexamethasone phosphate 0.1% ophthalmic drops every 4-6 hours post-operatively.
Group two: who received only Moxifloxacin 0.5% every 6 hours and Dexamethasone phosphate 0.1% ophthalmic drops every 4-6hrs without the administration of bromfenac 0.09% ophthalmic drops post-operatively.
Results: Eighty-seven eyes of 87 patients are enrolled in the study; the preoperative mean of intraocular pressure in group one and group two were 16.58 ± 2.37 mmHg and 17.14 ± 3.33 mmHg, respectively, with a p-value of 0.365, while the postoperative mean of intraocular pressure in group one and group two was 16 ± 2.32 mmHg and 16.68 ± 2.9 mmHg, respectively, with a p-value of 0.266, and all these are clinically insignificant. Also, there were no significant changes in IOP post-operatively in both groups, and the only side effect reported was punctate epithelial corneal erosion in five patients in group one.

Conclusion: The study demonstrated that bromfenac 0.09% ophthalmic drops had no significant effect on intraocular pressure (IOP) following phacoemulsification surgery and might cause punctate epithelium corneal erosion in some patients.