Inflammatory bowel disease (IBD) is chronic inflammation of the gastrointestinal tract (GIT) it includes two-condition Crohn’s disease (CD) and ulcerative colitis (UC) the prolonged inflammation may cause invasion of the multiple layers of the intestinal walls result in GIT damage. The current study was carried out in Baghdad teaching hospital and gastroenterology hospital from November 2021 to May 2022.  In order to show if the diagnostic marker of IBD which are IL6& calprotectin are rises in saliva as in sera and if there are significant differences in the levels of those markers between UC patients and healthy control subjects.

The subjects included twenty five patients suffering from ulcerative colitis and twenty five healthy individuals representing the control group. All of them having ages ranged between 20-55 years.

The recent study was measured the levels of Interleukin-6 (IL-6) and calprotectin in saliva of UC patients using ELISA method.

The present results showed a significant increase in the levels of both (IL-6) and calprotectin  in UC patients when compared with that of control group (P=<0.05).Moreover, this study was found a significant positive correlation between IL-6 levels and age in all study groups (UC and control) (P <0.05) and between IL-6 and calprotectin in UC patients(p<0.05).