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Evaluation of Brain Stem Function in Diabetics with and Without Distal Symmetrical Polyneuropathy Using the Blink Reflex
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 Background: Diabetic peripheral neuropathy (DPN) is the commonest complication of T2DM. Neuropathy is a descriptor for a spectrum of clinical and subclinical symptoms with varying anatomical distributions, clinical histories, and perhaps underlying pathogenetic mechanisms. The distal Symmetrical sensory polyneuropathy is chronic, symmetrical, length-dependent sensorimotor. Studies of the blink reflex have shown potential as a method of assessing brainstem activity.

Objective: The primary purpose of this research was to assess the function of the blink reflex in the early detection of cranial nerves and brain stem dysfunction in diabetes patients with and without polyneuropathy. We also aimed to see whether there were differences in blink reflex abnormalities between diabetes individuals with and without polyneuropathy.

Patients and Methods: The study included a group of sixty-60 diabetic patients. Clinician and electrophysiologist evaluations were used to determine the severity of neuropathy. Patients with diabetes were separated into two groups: those with and without neuropathy.

Results: A statistically significant difference between the two groups was for C.R.2 latency, and I.R.2 latency with a P-value <0.001. Except for blink reflex’s R1 latency (P-value >0.2), all other Blink reflex parameters were statistically different between patients who experience diabetic neuropathy and those who didn’t. Regarding HbA1c, a significant positive association with IR2 latency and C.R.2 latency was noted (Pvalue <0.001) and also, a statistically significant negative association was found with I.R.2 duration and C.R.2 duration (P-value <0.001). Amplitudes of sural, tibial and peroneal nerves were negatively associated with Blink reflex Latencies and positively associated with blink reflex duration.

Conclusion: In conclusion, blink-reflex parameters (including ipsi-lateral R.2 latency, contra-lateral R.2 latency) are significantly associated with HBA1C level and degree of peripheral diabetic neuropathy.

Received Sept. 2022

Accepted Nov. 2023

Published Jan. 2024

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Publication Date
Tue Jul 01 2014
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Evaluation of Auditory Brainstem Response test in comparison with other standard Behavioral tests results
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Background: There has always been a need for valuable measurements that can be used to measure hearing loss degree in patient who cannot responses to the subjective (behavioral) tests.

Objectives: to examine the accuracy of the click - Auditory Brain stem Response (ABR) test in estimating the hearing loss degree in comparison with the behavioral tests {Free Field (FF)  or Pure Tone Audiometry (PTA )}.

Subjects and method: One hundred twenty one children, with suspected hearing loss, their age between 1-9 year, 51 females and 70 males were examined in this work.
Result
: The relationship between the hearing loss thresholds using the behavioral 

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Publication Date
Sun Apr 02 2017
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Evaluation of Myocardial Function in Cases of Gestational Hypertension Using Myocardial Performance Index
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Background: Gestational hypertension represents a transient period of elevated blood pressure with  special effects on the maternal left ventricle that is different from the effects observed in chronic essential   hypertension; it affects a previously normal heart and lasts for a maximum of nine months associated with   volume and pressure overload on the maternal heart. Tei index (also called myocardial performance index)   was found to be a dependent combined index evaluating the systolic and diastolic function of the left   ventricle and represents a sensitive indicator for many types of heart diseases.
Objective: to evaluate the effects of gestational hypertension on the maternal myocar

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Publication Date
Thu Jan 02 2014
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The Role of Brainstem Auditory Evoked Potential Study in Patients With Moderate Closed Head Injury
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Background: The high prevalence of head injury among civilian populations and the provision of the adequate hospitals services have become matters of worldwide concern. Brain-stem auditory evoked potentials (BAEPs) have been shown to be of highly resistant to systemic factors and toxic or metabolic derangements, making them particularly useful in differentiating reversible brain-stem dysfunction from that due to structural disruption.

Objectives: The purpose of this study was to demonstrate the changes in   brainstem evoked response (BAER( in patient with moderate closed head injury and   assessing again these changes in BAER six months later as follow up indices.

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Publication Date
Sun Feb 21 2021
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Early onset familial relapsing polyneuropathy, mimicking CIDP; A lesson from clinical genetics
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Background: In children, chronic immune-mediated neuropathies present with slowly progressive or relapsing episodes of gait difficulty, symmetric weakness and sometimes paraesthesia. Infancy and early childhood age of presentation and familial recurrence are believed to be atypical features.

Case presentation: Herein, we describe two brothers from a non- consanguineous Iraqi family, who presented with episodes of acute immune-mediated demyelinating peripheral neuropathy in early infancy that relapsed recurrently. Mild haemolytic anaemia was also reported. Inherited metabolic disorders were suspected and Whole Exome Sequencing of the youngest brother revealed homozygous frame shift mutation in CD5

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Publication Date
Thu Apr 27 2023
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Effects of hypertension with and without smoking on salivary electrolytes concentration
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Background: Hypertension from smoking is a chronic medical condition that impacts human health. It has been proved that it could be a significant risk factor for different disorders like brain damage, the lung disease and has been related to the growth of oral diseases. However, there are few and conflicting research on its effect on salivary electrolytes concentrations.

Aim of the study: To assess the effect of hypertension with and without smoking on electrolyte concentrations in saliva and to identify its effect on normal oral balance.

Methods: A total number of 90 subjects included, which is comprised of (49) (54.4 %) males subjects and (41) (45.6 %) females subjects in

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Publication Date
Sat Jul 01 2023
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The Relationship between Levels of Serum Vit. D and Kidney Function in Diabetic Nephropathy Iraqi Patient: The relationship between vitamin D and diabetes nephropathy
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Background: According to several animal and human studies, Vitamin D appears to play a substantial role in the development of diabetic nephropathy, However, the possibility of vitamin D's Reno protective impact and influence on the reversal of already-existing renal damage remains speculative. Vitamin D deficiency and insufficiency are ubiquitous worldwide and have been linked to a variety of pathophysiological conditions, including diabetes, allergies, autoimmune illnesses, pregnancy difficulties, and, more recently, worse COVID-19 clinical outcomes. From a translational perspective, the goal of this review is to look into the potential function of vitamin D in the development of diabetic kidney diseases

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Publication Date
Sun Jan 03 2010
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Evaluation of left ventricular function in diabetics with ischemic heart disease
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Background: Diabetes mellitus is a major risk factor for coronary artery disease, with a higher incidence of myocardial infarction and sudden death. Left ventricular dysfunction is difficult to diagnose and to differentiate into diastolic and systolic dysfunction on the basis of medical history, physical examination, electrocardiography (ECC) and chest radiography. Two-dimensional, M-mode, and Doppler echocardiography are excellent for diagnosing left ventricular dysfunction. M-mode echocardiography was used for diagnosing left ventricular systolic dysfunction, while Doppler echocardiography has become well accepted as a reliable, reproducible and practical noninvasive method for the diagnosis of left v

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Publication Date
Mon Apr 01 2013
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Evaluation of Ankle-Brachial Pressure Index and Carotid Intima Media Thickness by Doppler Ultrasound in type two Diabetics.
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Background: Atherosclerosis causes thickening of the artery walls. The intima-media thickness (IMT) of the common carotid artery (CCA) is widely used as an early indicator of the development of coronary artery disease, atherosclerosis, and independently cardiovascular disease (CVD). Diabetes increased the risk of cardiovascular disease, also accelerates the common IMT progression. The Sonographic measurement of carotid intima-media thickness is used as a valid simple and noninvasive method for the assessment of atherosclerosis disease.

Also the ankle brachial index (ABI) is considered as a strong predictor for future cardiovascular events, and a golden standard for the diagnosis of peripheral arterial disease (PA

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Publication Date
Wed Sep 27 2023
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Assessment of Serum Levels of Advanced Oxidation Protein Products in Type 2 Diabetic Patients with and without Retinopathy Taking Different Antidiabetic Treatments
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The goal of this study was to investigate the protein peroxidation role by measuring serum levels of advanced oxidation protein products (AOPP) in type 2 diabetic patients with or without retinopathy and comparing them to controls to see if circulating AOPP levels can be used as a detection biomarker for DR. And see which of the two widely used antidiabetic treatment groups had the most impact on this oxidative stress marker. The groups were divided into two subgroups: 1) 70 type 2 diabetic patients (36 male, 34 female), 35 with diabetic retinopathy (DR) and 35 with no evidence of DR, and 2) non-diabetic controls (11 male, 9 female) were chosen from Ibn AL-Haitham Hospital for Ophthalmology and a Specialized Center for Endocrinology and Dia

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Publication Date
Mon Oct 17 2022
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Evaluation of the Role of Serum Malondialdehyde in the Pathogenesis of Diabetic Retinopathy
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Background:  The most typical consequence of diabetes mellitus is diabetic retinopathy. An important part of the etiology of diabetes and diabetic retinopathy is played by oxidative stress. Malondialdehyde is a dialdehyde that is moderately toxic and is frequently used as a marker for oxidative stress as well as lipid peroxidation.                    

Objectives: To assess the serum malondialdehyde levels in diabetic patients with and those without retinopathy and to compare these levels to controls .In additions to, investigate the relationship between serum malondialdehyde level and long glycemic control, the glycated hemoglobin (HbA1c).

Pati

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