Background: Extensive reports denote the biological role of trace elements (Cu Zn ", Se ') in many various physiological and pathological conditions, one of the list is shown to be Behcet's disease (BD).The aim of this study was directed towards the distribution of trace elements (Cu 2,Zn, 2,Se 2) in sera of BD patients, and control groups.
Methods: Fifty Arab Iraqi patients who fulfdled the ISO criteria for diagnosis BD.compared with 21 patients control with recurrent oral ulcer (ROU), healthy control groups (2Ihealthy relative and 21healthy volunteer). Typing HLA Class I was carried out at Alkarama hospital, by using microlympho-cytotoxicity test. The concentrations of serum Cu ', Zn ", and Se" were determined by atomic absorption spectrophotometry.
Result: Variation in levels of these trace elements as significant (P < 0.001) in Cu+2concentral and decreased (P<o.001) in Se+2 concentrate were clearly noticed in patients with BD in comparison to control groups.
Conclusions: Very unique striking results have come out of this study, and that is the significant increase in Cur2 level, significant decrease in Se 2 level, with non significanl decrease in Zn 2 level, were clearly observed in the patients studied groups in comparison with control groups. These results is another additional explanation to increase joint involvement occurrence in those patients ( our further documented results).