Background: Preeclampsia is most common medical disordersduring pregnancy, and the rate of hypertension ranges from 5 – 8 % f or all types of pregnancy. There was a significant difference between cancer antigen -125, plasma fibrinogen and C- reactive protein to the severity of preeclampsia.
Objective: To determine the level ofserum CA-125 level, C-reactive protein and plasma fibrinogen in preeclampsia and their association with the severity of disease and progression of mild preeclampsia to severe type.
Patients and method: A prospective case-control studywhich was carried out in the department of gynecology and obstetric at Baghdad teaching hospital from 1st ofJanuary 2015 to 1st of July 2015.One hundred forty pregnant women were included; they were selected and divided into three groups:
Group A: Thirty five (35) pregnant women with mild preeclampsia.
Group B: Thirty five(35) pregnant women with severe preeclampsia.
Both group A and B are selected according to the clinical signs, symptoms and investigations and admitted to obstetrics ward for evaluation.
Group C: seventy (70) pregnant women with uncomplicated singleton pregnancies as control group .
Blood samples were taken for measurement of serum cancer antigen -125, C- reactive protein and plasma fibrinogen for all groups
Results: The mean level of Cancer antigen- 125in control , mild and severe preeclampsia groups was ( 14.4±4.11) , (33.60± 4.52) and ( 37.35± 4.85) respectively which was a significant difference between control ,mild groups ( p value < 0.0001) and between control and severe preeclampsia groups ( p value < 0.0001), the mean level of C-reactive protein in mild and severe preeclampsia was( 15.62± 2.6)and ( 29.3± 7.02) which was significant higher in comparison to control group which was ( 8.17 ± 1.56 ) the P value was < 0.0001 . theplasma fibrinogen levels in mild and sever preeclampsia was (470.37±51.1) and (563.14±48.28) which were markedly higher than that of control group (342. 97±56.6) in third trimester pregnant women.
Conclusion:Serum Cancer antigen -125, Serum C - reactive protein and Serum plasma fibrinogen were significantly higher in preeclampsia groups in comparison to the control group and these increments was directly correlated with the severity of preeclampsia .
Background: Inflammation and more specifically inflammatory cytokines are determinant in the development of microvascular diabetic complications, including neuropathy, retinopathy and nephropathy.
Objective: The aim of present study is to evaluate the relationships between high sensitive C-reactive protein, microalbuminuria and risk factors for cardiovascular disease.
Subjects and methods: the study involved (30) patients with type 1 diabetic mellitus compared to (30) healthy control. A fasting blood sample was drawn from all subjects after an overnight fasting to measure the biochemical parameters which including glycated hemoglobin, lipid profile, atherogenic index of plasma and high sensitive C-reactive protein concentration in
Background: preeclampsia is characterized by endothelial dysfunction with vasoconstriction due to cell adhesion molecules or mediators released by defective placentation. Soluble platelet selectin, one of the cell adhesion molecules, is elevated in many inflammatory conditions including preeclampsia.
Objective: To investigate if soluble platelet-selectin levels can be used as a marker for adverse outcomes in pregnancy complicated with sever preeclampsia
Patients and methods:This study involved 115 pregnant women in their third trimester of pregnancy; divided into Group A: involves 25 pregnant women with preeclampsia complicated by intrauterine growth restriction.Group B: involves 35 pregnant women with preeclampsia without intraute
Background: Obesity is a medical condition in which excess body fat has accumulated to the extent that it has an adverse effect on health. . It measured by BMI (body mass index), obesity is considered when the BMI is ≥ 30 kg/m2. It increases the risk of coronary heart disease, Diabetes Mellitus and Cancer. Chronic inflammation and impaired fibrinolysis in obesity may induce thrombosis.
Aim of study: assess the effect of BMI (body mass index) on plasma level of Factor V and fibrinogen in obese and normal weight subjects.
Methods: This study was started on December 2015 and completed on June 2016, and included 51 obese attended alyarmouk Teaching Hospital. As well 2
... Show MoreBackground: Polycystic ovary syndrome (PCOS) is a common disorder in women in the reproductive age associated with disturbance of reproductive, endocrine and metabolic functions. The pathophysiology of PCOS appears to be multifactorial and polygenic.
Objective: To measure the level of prostate –specific antigen (PSA) and to evaluate the value of prostatic specific antigen as a marker of hyperandrogenism in women with PCOS.
Patients and Methods: One hundred women were entrolled in this study, 50 women were PCOS group and the remainder was healthy women served as control group. Hormonal profile (serum testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) levels were measured. Ferriman-Gallway Score (FGS) was as
Background: Since declaring coronavirus disease 19 as a pandemic by the World Health Organization, a great concern was directed toward pregnant women and their fetuses. Despite the substantial impact of COVID-19 disease on pregnancy, there is a scarcity of national researches discussing this important issue.
Objectives: To study the relationship between peripheral blood abnormalities and COVID-19 in pregnant women.
Patients and methods: A case control study was conducted in the labour wards of Baghdad Teaching Hospital in the Medical complex / Baghdad /Iraq during the period from 1st of February till 31st of July, 2021. Fifty pregna
... Show MoreBackground: disturbed physiological rhythm of blood pressure in preeclampsia is a common finding. The role of oxidative stress in pathogenesis of preeclampsia is well accepted. Melatonin is a powerful free radical scavenger so it's rapidly consumed by enhanced reactive oxygen species in preeclampsia causing non-dipping in blood pressure.
Objective: To evaluate the change in plasma melatonin levels in patients with preeclampsia and its relationship with blood pressure.
Patients and methods: In this prospective case control study a total of 40 primigravidae pregnant women were recruited during the period of 11 months between August 2015 and August 2016 in Baghdad teaching hospital, medical city, Iraq, divided into two groups:
Firs
Background: Preeclampsia is a pregnancy-specific, multisystem condition characterized by the onset of de novo hypertension and proteinuria occurring in previously normotensive women after the twentieth week of pregnancy. Pregnancy is associated with a physiological adaptation that leads to changes in the hematological system including platelet parameters.
Objectives: Is to compare platelet count, and platelet indices, namely mean platelet volume platelet distribution width and platelet count to mean platelet volume MPV ratio in preeclamptic patients with normal pregnant women.
Patients &a
... Show MoreBackground: Polycystic ovarian syndrome is the most common endocrine disease in females of childbearing time of life. Women with polycystic ovarian syndrome have a higher chance of developing complications such as dyslipidemia, hypertension, and obesity. Obesity is a state of extreme fat buildup which leads to the development of multiple complications involving non-alcoholic fatty liver disease, cardiovascular disease and type2 diabetes mellitus. Podocalyxin is an element of the endothelial cells plasma membranes that is widely spread, it is limited to the luminal membrane area and is irregularly located on the surface of endothelial cells lining blood ves
... Show MoreBackground: Acute phase proteins which include C-reactive protein (CRP) and haptoglobin (Hp) are associated with inflammatory diseases such as injury, infection or malignancy, cardiovascular disease and obesity. Atherogenic index of plasma (AIP) evaluated as the atherogenicity index is correlated with different diseases.
Objective : The study was to investigate hs-CRP and Hp concentration in Iraqi patients with coronary artery disease (CAD) and calculate AIP which predicts this disease.
Subject and Method: The study included 64 subjects (39 patients with CAD and 25 healthy subjects as a control group). The markers of inflammatory hs-CRP and Hp levels were measured. Lipid profile (Total cholesterol TC,