Background Cadmium (Cd), one of the most abundant heavy metals, is extremely toxic to both humans and animals. hIt is well known that zinc (Zn) administration reduces Cd-induced toxicity and that metallothioneins can have a protective effect in biological systems to mitigate Cd toxicity. Objective The aim of the current study to determine if Zn administration affected the induction of MT-1 and MT-2 in the liver tissue in mice exposed to Cd. Materials and methods Metallothionein protein (MT) level in the tissue of male mice were detected using the anion -exchang high-performance liquid chromatography coupled (HPLC)assay and immunohistochemical staining. Results Single treatment to zinc or cadmium increase the level of MT in the liver, but zi

The heavy metal cadmium is extremely harmful to both humans and animals. Zinc supplementation protects the biological system and reduces cadmium-induced toxicity. This study aimed to determine whether zinc chloride (ZnCl2) could protect male mice with the damaged liver induced by cadmium chloride (CdCl2). The protective role of zinc chloride and expression of the metallothionein (MT), Ki-67, and Bcl-2 apoptotic proteins in hepatocytes were studied after subchronic exposure of mice to cadmium chloride for 21 days. Thirty male mice were randomly categorized into 6 groups (5 mice/group) as follows: a control group that did not receive any treatment, a group given ZnCl2 at 10 mg/kg alone, and two groups received ZnCl2 (10 mg/kg) i

The  present   research   was  conducted   to  determine   the  effect  of Cadmium   Chlori de  on  the  t  stes  and  epididymis  of  white  mice  fed with  diffl rent  concentration     (75,  1 00 150  ppm)  of this hea  y metal for three,   ix and nine days. The r   ults showed  that cadm i um chloride caused   s  vera!  histopathalogical  change in  testes  and  epidid   mis in  luding deg  neration and cell necrosis  in addition  to the appearanc of  haemorrh

Background: Cadmium is highly toxic and carcinogenic environmental contaminant exposure to cadmium has been reported to reduce male fertility and there are several hypotheses that suggest how reduced male fertility may result from incorporation of cadmium. The purpose of this study was to determined the role of testicular ascorbic acid level in cadmium mediated oxidative damage on mice testis.
Objectives:To know the extent of toxicity of cadmium chloride and its adverse effects on male reproductive system in mice .
Methods:Fifteen adult albino male mice were divided into three groups, group one control and two experimental groups (low dose and high dose ).the experimental groups were injected with sing

Autoimmune hepatitis is an inflammatory disease and its incidence has been increasing. The features of hepatitis are the release of inflammatory cytokines, the elevation of AST and ALT, and hepatocyte apoptosis and necrosis. Concanavalin A considered as essential model represents the acute immune-mediated liver damage in rodents. Thymoquinone is well known herbal compound that exert hepatoprotective, anti-inflammatory, and antioxidant activity. In this study, we focus on the immunoregulatory and liver protective effect of thymoquinone in a mouse model of concanavalin A-induced liver injury.

Twenty-four male mice were randomly divided into four groups each containing six animals: Negative control group, concanavalin A model group,

Plants commonly used in traditional medicine are assumed to be safe. This safety is based on their long usage in the treatment of diseases according to knowledge accumulated over centuries. One such plants is Aloe vera which has been used medicinally for centuries. Recent widespread importance of commercial Aloe vera has encouraged scientists to scientifically assess these products since it contains the anthraquinones which associated with considerable risks. In present study oral administration of 20 μl of Aloe vera extract (experimental group) (G) was given for 21 days to immature male Swiss Webster mice at weaning period. While the control groups (C) were given by the same dose and rout of administration with normal saline only. Afte

This study was carried out to evaluate the hepato-protective property of (Arachis hypogea L.) peanut skin extracts in CCl4 induced hepatotoxicity in mice. The antioxidant activity was measured utilizing 2, 2-diphenyl-1-1 picrylhydrazyl (DPPH) radical scavenging capacity. The results showed that the methanolic extract was the highest free radical scavenging activity than the aqueous extract with values (92.34 ± 0.45 and 87.62 ± 0.44) respectively in 12 mg/mL compared to 89.61 ± 0.34 for Butylated hydroxytoluene (BHT) and 93.25 ± 0.06 for vitamin C, which means that the methanolic extract of peanut skin is superior to BHT. Furthermore, the total phenolic content was analyzed by using Folin-Ciocalteu method, the amount of total phenol in a

The present study including determined pathological changes in Barbus sharpeyi, as
well as description behavior and growth of bunni fish by used 180 fingerlings, Fish
were distributed randomly upon four treatments in addition to control group. First
treatment (T1) contained cadmium 0.093mg/L with changing water and added cadmium
continuously, the second treatment (T2) contained cadmium 0.093mg/L with changing
water without adding cadmium, third treatment (T3) contained cadmium 0.046mg/L
with changing water and adding cadmium continuously, fourth treatment (T4) contained
cadmium 0.046mg/L with changing water without adding cadmium. In order to estimate
LC50 used 120 fingerlings of fish B. sharpeyi, were exposed to