The monocyte chemo-attractant protein-1 (MCP-1) is one of the pro-inflammatory cytokines. It controls the passage and infiltration of monocytes, macrophages, natural killers, and T cells into the sites of inflammation. The aim of this study is to inspect the role of MCP-1 in maternal metabolic, physiological changes and pregnancy complications like gestational diabetes mellitus, dyslipidemia, and hypertension to develop pharmaceutical strategies for these complications. This study included ninety Iraqi women divided into three groups: thirty pregnant women in their first trimester as the P1 group; thirty pregnant women in their third trimester as the P2 group; and thirty healthy non-pregnant women as the control or C group. Serum concentrations of MCP-1 were analyzed by the ELISA technique (sandwich principle). Fasting plasma glucose (FPG), C-reactive protein (CRP), fasting serum insulin (FSI), glycosylated hemoglobin (HbA1c), lipid profile, systolic, diastolic blood pressure, liver function enzymes ALT, AST and anthropometric parameters were measured. Our results revealed that serum MCP-1 significantly declined in the first trimester (P1) compared to the C group (p<0.05) and non-significantly declined in the third trimester (P2) compared to that in the C group, while there was a significant difference in serum MCP-1 between the P1 and P2 groups (p<0.05 ). Serum CRP showed a highly significant increase in the P1 and P2 groups compared to the C group at (p<0.01). There is a highly significant difference between the P1 and P2 groups (p<0.01). Serum MCP-1 had a significant positive correlation with body mass index (BMI), body fat percentage (BF %), systolic blood pressure (SBP) and C-reactive protein (CRP) in the P2 group (p<0.05). No significant differences in FPG or HbA1C were found between all the studied groups. Lipid parameters: TC, TG, LDL, and VLDL showed a highly significant increase in the P2 group compared to the C and P1 groups (p<0.01). HDL showed a highly significant decrease in the P2 group compared to the C group (p<0.01), while it was only significantly decreased in the P2 group compared to the P1 group (p<0.05). Depending on these results, we found that serum MCP-1 declines in pregnancy, the BMI, BF%, and the contractile arterial blood pressure (SBP) have a positive correlation with MCP-1 in late pregnancy, and the inflammation marker (CRP) has an independent association with MCP-1 in early gestation.
Till now, isatin derivatives have received a lot of interest in organic and medicinal chemistry due to their significant biological and pharmacological activities. Schiff’s and Mannich bases of isatins are an effective group of heterocyclic derivatives that play a significant role in medicinal chemistry as antimicrobial agents. In light of these facts, new Schiff bases and Mannich bases of isatin were synthesized. The monomer Mannich bases; 3(a-e) have been synthesized by reacting isatin with different secondary amines, piperidine, morpholine, and pyrrolidine, dimethylamine, diphenylamine, separately, and formaldehyde, while the dimer (5) formed by using piperazine and formaldehyde which then react separately with Phenylhydrazine
... Show MoreIt was found that there was a significant correlation between all tests of the mechanical and electrical activity of the heart (systolic force FC, stroke volume SV, end-diastolic volume, EF volume, and left ventricular volume during diastole LVDD) with the test of the oxygen-phosphating energy system (Markaria). - As safe (Margaria-Kalamen( It was found that there is a significant correlation between all tests of the mechanical and electrical activity of the heart (myocardial systolic force FC, stroke volume SV, end-diastolic volume EDV, and the percentage of heart pumpingEF blood, and left ventricular volume during diastole (LVDD) with the Lactational Oxygen Energy System Test (Wingate Test 30 Second(
The study aims to measure and evaluate the return and the risk formulas of Islamic finance of Jordan during the period (2000 – 2009) according of increasing importance of these banks in recent and coming years to face challenges to maximize returns and minimize risks through financing with Islamic formula to investigate of existence statistical significant relationship between returns and risking Islamic bank , has been use of financial other statistical measurement. Measuring return and risk of Islamic banks have not been widely considered ,except in few descriptive studies . The controversy among academic and professionals about hot to measure and evaluate a comprehe
... Show MoreThe Tigris River in Iraq is of highly meandering in several of its parts. So, the largest meandering inside Baghdad City, is in Al-Jadriyah. During its course, the Tigris Riverbanks are facing erosion frequently due to alteration in the geomorphological and hydrological characteristics affecting the river channel. The entire length of Tigris River from the northern entrance of Baghdad to the convergence with Diyala River at southern of Baghdad is about 49 km length. The Tigris River is suffering from the erosion, deposition, and migration conditions. The river migration was found as maximum in the left bank at the side of the University, and lesser in the right bank in the opposite side, Dora. The aim of this study is to measure the magn
... Show MoreMarketing Intelligence is one of the important methods of collecting information about competitors ' products and changes in customers ' tastes and needs that contribute to determining the policies to be followed in product development.
The problem of research, which seeks to be answered by the extent to which the companies in question have the appropriate and effective mechanisms to develop their products, and the nature of the relationship between the components of marketing intelligence and new product development policies. The importance of research is determined by the importance of obtaining important and necessary information to make the appropriate decision on the development of the new product an
... Show MoreThe current research aims to identify the problems and needs for both college of political science and college of engineering’s students. The sample was (100) male and female student. The results showed bunch of problems which could be organized descendingly, the scientific domain ranged between (2 - 2.42), the mean of the psychological domain was (2.85), the moral domain ranged between (2.2 – 2.28)m the problems of study earned (2.30), the material domain got (1.95), the medical and social domain obtained (1.925), and finally, the family domain received (1.887).
Complications associated with diabetes are a consequence of acute disturbance in glucose metabolism in a human body. The most significant complication of diabetes is bone disorders which contributes to high levels of bone disability. This study included 118 diabetic patients, 56 males, 62 females, and 60 healthy non-diabetic controls, 30 males, 30 females. The patients and controls were age matched. Circulating levels of bone function markers (osteoprotegerin, vitamin D, PTH, total calcium and inorganic phosphorus) were determined in all subject groups. The data obtained from this study showed that the serum levels of osteoprotegerin had significantly increased in both diabetic male & female in both age ranges which were 4
... Show MoreOne hundred thirty four urine samples were collected from diabetic patients during the period from March –November -2014. From these samples there were 62.7% positive samples, women represented 45.3% and men represented 54.7% , some of them were a symptomatic as women represented 60.5% and men represented 58.7% and some were with clinical symptoms with or without a history of UTI. Hypertension diabetic women represented 45% and men represented 26% .Men suffering from prostate enlargement were represented 35% from the total diabetics .The E.coli isolates were represented 28.6% from the total cases ,Klebsiella spp isolates represented 20%, S. aureus isolates represented 16.7%,P
... Show MoreAim: To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. Methods: This study was conducted on 33 biopsies obtained from patients with OSCC and 10 normal oral mucosa as controls. In situ hybridization (ISH) was used to investigate the presence of HPV-16, while immunohistochemistry (IHC) was used to estimate the expression level of TIMP-2. Results: The TIMP-2 was expressed in 27 (81.8%) of OSCC sections with no significant difference between its expression level in HPV-16 positive and HPV-16 negative OSCC cases (p=0.058). TIMP-2 was found to be hig
... Show MoreThis research aims to determine the extent of the contribution of organizational downsizing strategies to enhance the health of the researched organization represented by the Directorate of Education in Nineveh, and to achieve this goal, the study provided a simplified intellectual framework for the most important topics covered by writers and researchers for search variables, reinforced by an applied analytical framework for the opinions of (79) individuals responsible for the researched organization. The research adopted organizational downsizing as an independent variable that includes three dimensions represented by (reduction of human resources, job redesign, systemic strategy), while the organizational health represented th
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