Let R be a Γ-ring and G be an RΓ-module. A proper RΓ-submodule S of G is said to be semiprime RΓ-submodule if for any ideal I of a Γ-ring R and for any RΓ-submodule A of G such that or which implies that . The purpose of this paper is to introduce interesting results of semiprime RΓ-submodule of RΓ-module which represents a generalization of semiprime submodules.