CYTOTOXICITY OF NON-BOUND COLICINS EXTRACTED FROMEscherichia coil ON NORMAL WHITE BLOOD CELLS ANDMYELOBLAST ISOLATED FROM ACUTE MYELOID LEUKEMIABLOOD PATIENTS
CYTOTOXICITY
COLICINS
coil
Four types of non-bound colicins (H٥, H٩, H١٣, H١٩) were extracted from
intestinal normal flora Escherichia coil isolated from healthy people’s stool. Then
study cytotoxic effect of colicins on normal white blood cells (WBCs) from healthy
people. And cytotoxicity on myeloblasts isolated from AML patients blood. Results
showed, myeloblasts from AML patients were more sensitive to colicins than
normal WBCs from healthy people.The toxic effect was dose-dependent and
exposure time.