SYNTHESIS AND IDENTIFICATION OF SCHIFF BASES AND BILOGICAL ACTIVITY NEW STUDY
Open Schiff base
Macrocyclic
Salicylaldehyde
Spectral Technique
Antimicrobial Activity.
In this work we focused on the synthesis of new Open Schiff bases which were
prepared by condensation of salicylaldehyde with both 4,4'-diaminodiphenyl
methane,4,4'-diamino diphenyl sulphide,and by condensation of O-vanilin with
diethyl ester of terephthalic acid respectively.Also new macrocyclic Schiff Bases
were prepared by condensation of 1,6-bis(2-formylphenyl)hexane with
thiocarbohydrazid.The Schiff bases were checked by different spectral technique
(LC-MS, 1H-NMR, IR). The work was extended to study the effect of the prepared
compounds on four different bacteria in order to test there biological activity