In this study, novel derivatives have been synthesized for 1,2,4-triazole-quinazolinone compounds. The intermediate compound, amic acid 1, was prepared through the reaction of anthranilic acid with para-methoxybenzoyl chloride. The compound benzoxazinone 2 is prepared by reacting amic acid with acetic anhydride, which upon esterification is carried out using ethylglycinate hydrochloride. Ester derivative 3 was obtained. The first line of research involved reacting the ester derivative 3 with (semicarbazide, thiosemicarbazide, and phenylthiosemicarbazide, phenylthiosemicarbazide) respectively to give derivatives 5-8. Compounds 5-8 were cyclized in alkaline medium (2N-NaOH) gave 1, 2, 4-triazole derivatives 9-12, respectively. Alternatively, compound 4 was reacted with CS2 in an alkaline medium (20% KOH) to produce the potassium salt 13. This compound then directly reacted with aqueous hydrazine to yield compound 14. The new compositions prepared were proven using spectroscopic techniques [FT-IR, 1H-NMR, 13C-NMR,]. The last part of this research in which, these materials were tested 5, 9, 11, 12, 13, 14 for antioxidant activity using DPPH radical scavenging activity technology.
Synthesis, Identification of Some New 1, 2, 4-triazole Derivatives from 2-(4-methoxyphenyl)-3-ethyl acetate -4(3H) - quinazolinone and Evaluation Anti-Oxidant Activity
anthranilic
Semicarbazid
Thiosemicarbazide
1
2
4-triazole
Anti-oxidant