Obesity is complex and chronic  disease . it had negative impact on general health , quality of life and elevation in mortality rate . The liver is the most affected organs by obesity. The use of plants different active constituents which had different pharmacological effects. One of these constituents are the polyphenols which had  antioxidants and anti-inflammatory effects. Accordingly, polyphenols nowadays  have become one of the most important therapeutic protocols today. Acai berry extract's had different pharmacological benefits due to its  anti-inflammatory and antioxidant activity  The aim of the present study is to assess the hepatoprotective impact of acai berry extract in rats fed a diet rich in fat and carbohydrates. To achieve this aim, 48 albino rats were divided into  Group I. rats receive normal diets, group II: rats on high fats and carbohydrate diets, groups III , IV: rats on high carbohydrate and fat diets with Acai berry extract ( 250, 500mg/kg per day) respectively, groups V, VI; rats feed with high carbohydrate and fat diets with 10 mg/kg/day of orlistat and ( 250, 500mg/kg per day) respectively of acai berry extract. All the groups received their treatments for 12 weeks.  At the end of study, serum was collected, and liver tissue were obtained to determine anti-oxidative, inflammatory, and liver function. In the present study, it have been found that, there was a significant elevation in the level of (superoxide dismutase, glutathione peroxidase) in tissue homogenate (p <0.05)  and a significant reduction in the levels of liver function enzymes and (malondialdehyde, tumor necrosis factor alpha, tumour growth factors,interleukin-B1)( p < 0.05) when compared between groups III ,IV and the induction group. The present study showed that the extract of acai berries had hepatoprotective effects