In this study, a series of compounds (B1-B10) containing the (OR-) bond were prepared from nucleophilic substitution reaction of the Schiff base compound containing the (OH) group with different halides (alkyl halides, benzyl halides, benzoyl halides, sulfonyl halides) using the Williamson method. The prepared compounds were identified by FTIR, 1HNMR, and 13CNMR, then their effectiveness was evaluated against positive and negative gram bacterial and fungal and compared with two standard references (Ciprofloxacin ,Clotrimazole ). Overall , some of prepared compounds showed inhibition zone against Gram-positive and negative bacteria, and some compounds did not show inhibition zone while compound B1 showed moderate inhibitory activity against all tested bacteria compared to other derivatives. But all the tested compounds showed inhibition zone against fungal Candida albicans except compound B2 had no effect.
Synthesis, Characterization and Study Antimicrobial Activity of Isoniazid Derivatives
Nucleophilic substitution
Williamson
Isonicotinic acid hydrazide
halides
antimicrobial activity