Preferred Language
Articles
/
bijps-2030
Cytotoxic Evaluation of Doxorubicin Combination with Baicalein and Resveratrol Against Hct116 and Hepg2 Cancer Cell Lines (Conference Paper) #
...Show More Authors

Combination of natural poly-phenolic compounds with chemotherapeutic agents is recently being a novel strategy in cancer therapy researches owing to their potential antioxidant and anti-inflammatory properties that modulate several intracellular signaling pathways.

Resveratrol and Baicalein are well known poly-phenolic compounds that belong to stilbene and flavone subclasses, respectively.

This study aims to investigate the possible enhancement effect of resveratrol and Baicalein when combined with doxorubicin using a different combination ratio and applied on two cancer cell lines: HCT116 (colorectal cancer cells) and HepG2 (hepatocellular cancer cells). It also investigates the possibility of such natural compounds to provide a protection effect on cardiocytes (H9C2) when resveratrol and Baicalein treatment followed by doxorubicin is used. 

The two cancer cell lines were treated with different combination groups, including the combination between doxorubicin and Baicalein or resveratrol and the combination between the three compounds using a different combination ratio for both treatment groups (i.e., two drugs or three drugs combination). Treatment applied on cells, using cell density of 7000 cells /well and incubation time was 48 hrs. MTT test was performed to assay the cell viability.

The results obtained showed that the cytotoxicity of doxorubicin in the two cancer cell lines has increased when combined with Baicalein and resveratrol. Doxorubicin IC50 decreased from 4.99 µg/ml to 0.3657 µg/ml and from 7.3 µg/ml to 0.676 µg/ml on HCT116 and HepG2 cells, respectively, using constant combination ratio (1:1:1).

The combination of doxorubicin, Baicalein, and resveratrol has resulted in a less cardiotoxic effect compared to treatment with doxorubicin alone. This decrease was obviously seen when the three compounds were combined using a low concentration range and with a constant combination ratio.

Conclusion: combinations of Baicalein and resveratrol with doxorubicin chemotherapeutic drug In Vitro had enhanced the cytotoxic activity of such a chemotherapeutic drug, while simultaneously eliminating its cardio-toxicity side effect.

 

Scopus Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Wed Oct 18 2023
Journal Name
Iraqi National Journal Of Nursing Specialties
Nurses' Knowledge and Practice about Cesarean Section
...Show More Authors

Objectives: The study aimed at the assessment of nurses' knowledge and practice concerning Cesarean Section.
Methodology: ٨ non-experimental approach was carried out throughout the present study with the application
of a descriptive design a for the study subject. The study was carried out at two maternity hospitals in Mosul
city namely Al-Barolo and AL Khansa Hospitals. ٨ purposively sample consist of (20) Nurse who are working
in operation theater. The questionnaire was used as a means of data collection; it comprised (3) major parts. Part
one presented the demographic data. Part two, consisted of items of Nurses’ knowledge about Cesarean Section.
While, part three consisted of items of Nurses’ practices about C

... Show More
View Publication Preview PDF
Publication Date
Mon Feb 04 2019
Journal Name
Journal Of The College Of Education For Women
Andalusian Woman Customs Traditions Challenge and Change
...Show More Authors

A study Andalusia woman in shade society Arabic Islamic conservative on social customs in respect instructions in the different cover and tongue and not reveal beautiful woman because she is development the honor conscience in the society and she is respect not mix with the men about fall what he said the law Islamic and belief that the Andalusian people prince Husham days ago and he entry dependence to the mawta book. But the Andalusia woman was having the freedom and boasting and the greatness and beautiful and not respected factions from Andalusia woman instruction religion fewness commitment in the tradition Arabian and Islamic her promiscuity her promiscuity in the Spanish society that it is different habits and traditions with soci

... Show More
View Publication Preview PDF
Publication Date
Tue May 01 2018
Journal Name
The Journal Of Immunology
Gut dysbiosis and immunological profile in endometriosis
...Show More Authors
Abstract<p>Ectopic growth of normal cells or debris originating from endometrium, the inner layer of female reproductive tube leads to endometriosis. The main symptoms are dyspareunia, dysmenorrhea, and sometimes chronic pelvic pain. Unfortunately, it has no cure or treatment, only symptoms relief medication or surgical removal. Endometriosis causes estrogen imbalance leading to intestinal bacterial estrobolome dysregulation and subsequent change in immune response. Our study aims to investigate the linkage between gut dysbiosis and immunological response in endometriotic mice. Balb/c mice were ovariectomized (OVX) 7 days before intraperitoneal transplantation of 2mm2 endometrial tissue from OVX</p> ... Show More
View Publication Preview PDF
Crossref
Publication Date
Wed Jun 01 2022
Journal Name
Innovations
Proteolytics, Their Functional Role and Practical Applications
...Show More Authors

RMK Al-Zaid, AT Al-Musawi, SJ Mohammad

View Publication
Publication Date
Fri Jan 01 2021
Journal Name
Italian Journal Of Pure And Applied Mathematics
Banach gamma-algebra modules and full stability
...Show More Authors

In this paper the full stable Banach gamma-algebra modules, fully stable Banach gamma-algebra modules relative to ideal are introduced. Some properties and characterizations of these classes of full stability are studied.

View Publication
Scopus
Publication Date
Fri Aug 23 2013
Journal Name
International Journal Of Computer Applications
Image Compression based on Quadtree and Polynomial
...Show More Authors

View Publication
Crossref (3)
Crossref
Publication Date
Sun Jul 01 2012
Journal Name
Journal Of Educational And Psychological Researches
Arabic Calligraphy quality standards and teaching methods
...Show More Authors

Arabic calligraphy is one of the ancient arts rooted in history, And that he grew up conflicting views and writings addressed as a, communication tool for the linguistic The teaching calligraphy note an art and science because it depends on the fixed assets and precise rules in his art because centered Beauty It targets teach Arabic calligraphy speed as the education and recitation helps to write fast Which have great interest in the field of education and in life both Also accompanied Arabic calligraphy and scientific renaissance significant knowledge in the Ara

... Show More
View Publication Preview PDF
Publication Date
Fri Feb 01 2019
Journal Name
Journal Of The College Of Education For Women
Baghdadin Drinks and Foods stuff Abbasyat Ages
...Show More Authors

Baghdadin Drinks and Foods stuff Abbasyat Ages

View Publication Preview PDF
Publication Date
Tue Jul 06 2010
Journal Name
Journal Of College Of Education
Association Between lnsulin Resistance And Diabetes Mellitus
...Show More Authors

Background: Obesity and diabetes mellitus are the common health problems,and obesity is common cause of the insulin resistance. Aim of studv: Aim of the study is to find any correlation between obesity (insulin resistance) and type I diabetes in children. Patients and methods: This study included (40) children with type I diabetes, in addition to (40) children as control.The age of all studied groups ranged from (8-18) years.This study was attemted from Ibn AlBalady Hospital during from 20 August to 9 Novembar,2008. The subjects wrer divided into (4) groups according to their BMI:- * Obese children,diabetes,n=2O,BMI>30. * Non obese children, diabetes, n=20,BMI<25. Obese children, non diabetes, n=20,BMI>30. * Non obese children,non diabetes

... Show More
Publication Date
Mon Feb 01 2016
Journal Name
2016 International Conference On Computing, Networking And Communications (icnc)
Connectivity and rendezvous in distributed DSA networks
...Show More Authors

In this paper, we use concepts and results from percolation theory to investigate and characterize the effects of multi-channels on the connectivity of Dynamic Spectrum Access networks. In particular, we focus on the scenario where the secondary nodes have plenty of vacant channels to choose from-a phenomenon which we define as channel abundance. To cope with the existence of multi-channels, we use two types of rendezvous protocols: naive ones which do not guarantee a common channel and advanced ones which do. We show that, with more channel abundance, even with the use of either type of rendezvous protocol, it becomes difficult for two nodes to agree on a common channel, thereby potentially remaining invisible to each other. We model this

... Show More
Scopus (2)
Crossref (1)
Scopus Crossref