Photosynthetic and biochemical characterization of in vitro-derived African violet (<i>Saintpaulia ionantha</i>H. Wendl) plants to ex vitro conditions
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(18)
Publication Date
Sat Feb 01 2025
Journal Name
Pharmaceutical Nanotechnology
Preparation, <i>In-vitro, Ex-vivo</i>, and Pharmacokinetic Study of Lasmiditan as Intranasal Nanoemulsion-based <i>In Situ</i> Gel
Background:
Objective:
Method:
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Bioavailability study
ex vivo permeation study
C-max
Lasmiditan
nanoemulsion-based in situ gel (NEIG)
T-max
aqueous-LAS suspension.
Lasmiditan (LAS) is a recently developed antimigraine drug and was approved in October, 2019 for the treatment of acute migraines; however, it suffers from low oral bioavailability, which is around 40%.
This study aimed to improve the LAS bioavailability via formulation as nanoemulsionbased in situ gel (NEIG) given intranasally and then compare the traditional aqueous-LASsuspension (AQS) with the two successful intranasal prepared formulations (NEIG 2 and NEIG 5) in order to determine its relative bioavailability (F-relative) via using rabbits.
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Publication Date
Wed Jan 01 2020
Journal Name
Research Journal Of Pharmacy And Technology
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(3)
Publication Date
Wed Jul 22 2015
Journal Name
Plant Growth Regulation
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(11)
Publication Date
Tue Sep 05 2017
Journal Name
Cell Adhesion & Migration
(63)
(20)
Publication Date
Thu Sep 01 2016
Journal Name
Journal Of Ocular Pharmacology And Therapeutics
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(15)
Publication Date
Thu Jul 11 2019
Journal Name
Turkish Journal Of Pharmaceutical Sciences
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(12)
Publication Date
Tue Jan 01 2019
Journal Name
Indian Journal Of Forensic Medicine & Toxicology
Publication Date
Fri Nov 01 2024
Journal Name
Heliyon
Publication Date
Mon May 07 2018
Journal Name
Human And Ecological Risk Assessment: An International Journal
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(17)
Publication Date
Sun Jan 01 2017
Journal Name
Food And Nutrition Sciences
Optimization of Culture Conditions to Produce Phytase from &lt;i&gt;Aspergillus tubingensis SKA&lt;/i&gt;
The effects of nutrients and physical conditions on phytase production were investigated with a recently isolated strain of Aspergillus tubingensis SKA under solid state fermentation on wheat bran. The nutrient factors investigated included carbon source, nitrogen source, phosphate source and concentration, metal ions (salts) and the physical parameters investigated included inoculum size, pH, temperature and fermentation duration. Our investigations revealed that optimal productivity of phytase was achieved using wheat bran supplemented with: 1.5% glucose. 0.5% (NH4)2SO4, 0.1% sodium phytate. Additionally, optimal physical conditions were 1 × 105 spore/g substrate, initial pH of 5.0, temperature of fermentation 30˚C and fermentation dura
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