Photosynthetic and biochemical characterization of in vitro-derived African violet (<i>Saintpaulia ionantha</i>H. Wendl) plants to ex vitro conditions
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Publication Date
Sat Feb 01 2025
Journal Name
Pharmaceutical Nanotechnology
Preparation, <i>In-vitro, Ex-vivo</i>, and Pharmacokinetic Study of Lasmiditan as Intranasal Nanoemulsion-based <i>In Situ</i> Gel
Background:
Objective:
Method:
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Bioavailability study
ex vivo permeation study
C-max
Lasmiditan
nanoemulsion-based in situ gel (NEIG)
T-max
aqueous-LAS suspension.
Lasmiditan (LAS) is a recently developed antimigraine drug and was approved in October, 2019 for the treatment of acute migraines; however, it suffers from low oral bioavailability, which is around 40%.
This study aimed to improve the LAS bioavailability via formulation as nanoemulsionbased in situ gel (NEIG) given intranasally and then compare the traditional aqueous-LASsuspension (AQS) with the two successful intranasal prepared formulations (NEIG 2 and NEIG 5) in order to determine its relative bioavailability (F-relative) via using rabbits.
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Publication Date
Wed Jul 22 2015
Journal Name
Plant Growth Regulation
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(11)
Publication Date
Wed Jan 01 2020
Journal Name
Research Journal Of Pharmacy And Technology
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(3)
Publication Date
Tue Sep 05 2017
Journal Name
Cell Adhesion & Migration
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(20)
Publication Date
Thu Sep 01 2016
Journal Name
Journal Of Ocular Pharmacology And Therapeutics
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(15)
Publication Date
Thu Jul 11 2019
Journal Name
Turkish Journal Of Pharmaceutical Sciences
(17)
(11)
Publication Date
Tue Jan 01 2019
Journal Name
Indian Journal Of Forensic Medicine & Toxicology
Publication Date
Fri Nov 01 2024
Journal Name
Heliyon
Publication Date
Mon May 07 2018
Journal Name
Human And Ecological Risk Assessment: An International Journal
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(16)
Publication Date
Thu Dec 19 2024
Journal Name
Annals Of Parasitology
Artemisinin efficacy against old world Leishmania donovani: in vitro and ex vivo study
Visceral leishmaniosis is one of the most fatal old-world neglected disease with estimated 90 thousand worldwide cases emerge each year. In Iraq, the cutaneous and visceral form are endemic but available chemotherapies are either toxic with diverse side effects, expensive available drugs or parasite …
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