The experiment was conducted in the botanical garden of the Department of Life Sciences/ College of Education for Pure Sciences Ibn Al-Haitham for the growing season 2021- 2020 in order to study the effect of urea and NPK fertilizer on some physiological characteristics of watercress plants. The seeds were sown on 10/15/2020 in plastic bags weighing 10 kg of soil. The shoots were sprayed with urea at three concentrations (0, 50, 100) mg L-1 in two sprays, and NPK fertilizer was added as a ground addition at three levels (0, 100, 200) kg H-1 in two sprays in conjunction with urea spraying. The results of the study showed a significant effect for the single treatments. The treatment of spraying with urea at a concentration of 50 mg l-1 . was superior to, and the treatment of NPK fertilizer at the level of 200 kg ha-1 by giving them the highest values compared with the measurement coefficients, and in the interaction coefficients between the study factors, the treatment (spraying with a concentration of 50 mg l-1 with NPK at a level of 200 kg ha-1 ) was superior, and the highest values were recorded for the number of leaves, dry weight of leaves and concentration Chlorophyll and the percentage of carbohydrates, nitrogen, phosphorous and potassium in the leaves were (29.00 leaf-1 , 12.55 gm plant-1 , 44.67 SPAD, 16.33%, 4.50%, 0.51% and 4.29%) compared with the control treatment that recorded values (15.33). Leaf-1 , 7.0712.55 g, Plant-1 , 32.68 SPAD, 8.58%, 3.07%, 0.24%, and 2.56%) respectively. The experiment was implemented according to the complete randomized sectors (RCBD) and the 9 transactions were randomly distributed. Coefficients and with three replicates, so that the number of experimental units was 27, and the averages were compared according to the LSD test at the 5% probability level. Keywords: urea, NPK fertilizer, watercress