Abstract: The study aimed to investigate the effect of oral administration of hot aqueous extract of beetle cocoon Larinus maculatus Faldermann, in a two doses 50 and100mg/Kg/B.wt for 3 and 6 weeks respectively on the levels of serum glucose, weight of body, and lipid profile in male mice Mus musculus. The results revealed that there was a significant (p<0.05) decrease in serum glucose level was dose and period dependent. Weight of body also reduced significantly (p<0.05) with doses and period dependent. The lipid profile level significantly (p<0.05) decreased in dose and period’s manner in each of Total cholesterol (TC), Triglyceride (TG), High Density Lipoprotein- (HDL), Low Density Lipoprotein (LDL), and Very Low Density Lipoprotein (VLDL). Results showed that the hot aqueous extract of beetle cocoon has side effect at two administered doses in present study, since the raw extract of this cocoon is used in people medicine to treat for respiratory inflammations in Iraq from decades. The study revealed that the extract have some undesirable effects on lipid profile, so must advise the people not to rush in using the extract of cocoon in therapy of chronic respiratory problems because it has other side effects in the body.
University of Baghdad
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