A total of 33 Iraq male positive for Toxoplasmosis and Iraq male negative for Toxoplasmosis (controls) were studies to Evaluation of some biochemical and immunological parameters changes.The parameters included lipid profile such as (Cholesterol(C), Triglycerides(TG), High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL) and very Low-Density Lipoprotein (VLDL) and complement component C3 and C4. The results revealed significant decrease in the total cholesterol, Triglycerides, LDL and non-significant in vLDL (129.96±1.63, 130.69± 2.80, 87.19±1.97, 29.24± 0.83 mg/dl respectively) and non-significant increase in HDL(24.22 ±0.62) mg/dl compared with control group(152.07± 1.63, 156.48± 6.55, 99.26 ±1.39, 31.49± 1.30 and 21.31± 0.36 mg/dl).The immunological tests recorded a significant increase in C3, C4 (150.60± 9.67, 31.47± 1.71 mg/dl respectively) compared with control group (52.86 ± 3.46, 15.15± 0.47 mg/dl respectively). There for these results reveal that the infection with Toxoplasma gondii may have an essential role in alterations of lipid profile levels and complement components in infected men.