Medicinal plants are used to treat various diseases although little is known about their toxicity. Coriandrum sativum is one of the most commonly plants that is used to treat several physiological disorders. Thus, this study was conducted to evaluate the effect of aqueous extract of C. sativum on the structure and function of liver in male albino mice. Thirty male mice were randomly divided into three groups: Group 1 untreated (control), Group 2 and 3 were administrated orally with the aqueous extract of the plant at dose 125 and 250 mg/kg. b. w. For 30 days. The effect of the extract on liver weights, biochemical parameters as well as histological study were assessed. There were no significant difference (P>0.05) observed in relative organ weights, serum Gpt and Got levels in mice treated with the extract at dose 125 mg/kg. b. w. while the histological section showed moderate degeneration in hepatocytes. However the treatment with 250 mg/kg. b. w. of the extract caused significant reduction (P<0.05) in liver relative weight,highly significant increased (P<0.01) in serum level of GPT and GOT as compared with control. Further histological examination revealed marked degeneration and distortion of hepatocyte, conjestion, inflammatory cells infiltration and cytoplasmic vaculation at dose of 250 mg/kg. b. w. these results suggest that oral administration of C. sativum leaves aqueous extract have a toxic effect on liver at dose 250 mg/kg. b. w.