Acromegaly is a rare disease produce generalize and serious alteration in the patient with active disease. Many of these patients are also diabetic. Many analytes, hormones, markers are change in these disease. The objective of study is to assess the modification in a number of parameters that changed during the acromegaly as a result of excess in GH and IGF1 levels. The study included 36 patients and 38 healthy controls, paired by sex and age and BMI. Serum concentration of GH and the other parameters including (insulin, glucose, lipid profile, uric acid ) were determined by biochemical method .Compared to controls, acromegalic patients had increased levels of GH, insulin, glucose, triglyceride, very low density lipoprotein(VLDL) (p<0.05) , High density lipoprotein (HDL) significantly reduce among acromegalic patients compared to the control group (p<0.05) . Non significant differences in total cholesterol, low density lipoprotein (LDL) levels between controls and patients group (p>.0.05)
SOME BIOCHEMICAL CHANGES AFTER TREATMENT IN IRAQIS
ACROMEGALIC PATIENTS
Acromegaly patients
diabetic
cholesterol
LDL
VLDL
GH etc
Publication Date
Sat Dec 01 2012
Journal Name
Advances In Bioresearch
Cytotoxicity of Miltefosine against Leishmania majorPromastigotes
Leishmaniasis has poor vaccination trials and the available drugs have side effects on patients. Therefore
development ofnew chemicals is important for public health. Miltefosine is the first drug used for oral treatment of visceral leishmaniasis.Previous studies approved that miltefosine is an effective treatment against visceral leishmaniasis
the visceral form ofLeishmania
and also on L. major
the cutaneous form of Leishmania. Here
we investigated the in vitro cytotoxicity ofmiltefosine on the procyclic promastigotes forms of L. major. Different concentrations of miltefosine were investigatedagainst the flagellated form of L. major
and results showed that miltefosine has inhibited the in vitro proliferation of theparasite
approving the cytotoxic effect of the compound on Leishmania
EC50 was determined after 24 hours exposure forthe drug and it was 1.54 μM. Our findings indicate that miltefosine has a cytotoxic effect on the insect stage of the old worldL. major and can be a new anti-Leishmanial drug