Background: obesity is nowadays a pandemic condition. Obese subjects are commonly characterized by musculoskeletal disorders and particularly by non-specific low back pain (LBP). However, the relationship between obesity and LBP remain to date unsupported by an objective measurement of the mechanical behavior of spine and it is morphology in obese subjects. . Objectives: To identify the relationship between obesity and LBP regarding (height, weight, sleeping, chronic diseases, smoking, and steroid). Method: A cross-sectional study was conducted from the first of January 2016 to January 2018 in obesity research and therapy unit at Alkindy medical college Baghdad, Iraq. 110 patients were eligible and enrolled in the study and dividing into two groups: the first group (group A) was obese female with LBP; the second group (group B) was obese female without LBP . Results: There is a significant relationship between body weight and LBP p-value (0.039), also there is a relation between diabetes mellitus type II (DM) and LBP p-value (0.004), there is no significant relationship between height, sleeping time ,nap hours ,hypertension ,rheumatoid arthritis ,steroid, asthma ,and smoking as P value>0.05. Conclusion: Obesity predisposes to LBP and, DM. So, awareness of weight reduction and lifestyle modification, exercise, healthy diet, further study are needed to determine the relation of LBP and BMI in multi obesity centers