Estimation of Serum Matrix Metalloproteinases-1 Levels in Iraqi Female
Patients with Osteoarthritis
ALP: Alkaline Phosphatase
OA: Osteoarthritis
CPC: o-Cresolphthalein Complexone
MMP: Matrix Metalloproteinases
RA: Rheumatoid Arthritis
SF: Synovial Fluid
This study was established to investigate the correlation between the expression of matrix metalloproteinases (MMP-1) and the pathogenesis of osteoarthritis (OA). Blood samples were collected from 55 female patients with inflammatory OA and controls for estimation of serum (MMP-1) levels. In the current study, there is significant increase (p<0.001) in the mean of serum MMP-1 levels in osteoarthritis females (4027.73 ± 1345.28 pg/ml) than that in control females (798.76 ± 136.79 pg/ml). It was concluded that MMP-1 may be associated with the pathogenesis of osteoarthritis.