This research aims at identifying the system of applying the QRcode system for acquisition of chemistry by first class female students studying at intermediate schools knowledge and its effect on creative thinking. The research sample consisted of (63) female students in one of the intermediate schools in Baghdad/Iraq using two equivalents experimental and control groups. The scientific context used was based on the chemistry text book related to the periodic table, (Metals) for the first group of students and Alkaline metals,Nonmetals, Metalloides) for the second group. The research methodology employed consisted of the followings :Measuring students acquisition using (35) issues. The results were verified for their face validity and obtaining referees agreement by (82%) and measuring the stability coefficient using Cronbach’s Alpha formula which produced a (89% (. The second part of the methodology was to measure the student’s creative thinking skill using 5 part test as suggested by (sayed khair allah, 1981) and as applied in many studies in Iraq. The test was verified by a group of experts in psychology and teaching methods and the agreement on the parts of the test was (92%) and after applying the test on the first sample of students, the stability coefficient measured was (%84( The results has shown a significance statistical difference in the acquisition and creative thinking variables between the two research groups in favour of the experimental group which used QR-code and creative thinking in their classes.