Photodynamic Therapy for Leiomyosarcoma: In vitro study

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16/7/2014 10:46 AM

Photodynamic Therapy for Leiomyosarcoma: In vitro study



Rajaa S. Abbas
Ali S. Mahmood
Institute of Laser for Postgraduate Studies, University ofBaghdad, Baghdad, Iraq
Eman H. Y. Al-Taee College of VeterinaryMedicine, University of Baghdad, Baghdad, Iraq
(Received 5May 2012; accepted 11June 2012)


Abstract:

Leiomyosarcoma (smooth muscle tumor) is a rare type of a malignant neoplasm of smooth muscle. It is a resistant cancer, generally not very responsive to chemotherapy, radiationand surgery.The aim of this study was to evaluate photodynamic therapy (PDT) as a possible basis for treatment using (650 nm)diode laser with methyleneblue (MB) as a photosensitizer on leiomyosarcoma (LMS)cell line (L20B) in vitro. The cytotoxic effects of 650nm diode laser 0.052 W/cm2 (power density) at different exposure time (10, 20, and 30 min) with methylene blue at different concentrations (0.01% ,0.1 % ,1%) was investigated on LMS cell line (L20 B). The cytotoxic effect of laser was increased with increasing irradiation time for a certain concentration of methylene blue. The exposure time 30 min of diode laser with 1% (MB) has the great inhibitory rate(IR)for LMS cells growth which reaches to 80.46% and reducing the proliferation rate (PR) which reaches to 19.54%.




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