Analgesic Effect of Melatonin in Mice

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02/4/2014 12:23 PM

Analgesic Effect of Melatonin in Mice

Imad Hashim Mohammad, M.Sc., Ph.D.

Background: Melatonin is the main hormone secreted by the pineal gland. This indole compound (N-acetyl-5-methoxytryptamine) is derived from serotonin after two biochemical steps. Melatonin has been implicated in some pharmacological effects including sedative/hypnotic, anticonvulsant activity and others. The aim of this study was to investigate the antinociceptive effect of different doses of melatonin administered i.p. to mice, and then, to find the dose- response line of melatonin in mice as analgesic agent.

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