VCAM-1 Expression in Endometerium with Human Cytomegalovirus Infection

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02/4/2014 10:07 AM

VCAM-1 Expression in Endometerium with Human Cytomegalovirus Infection
 

Asmaa B Al-Obaidi MBChB,MSc
Manal Adnan Habib MBChB,PhD
Shatha Al-ZuhairyMBChB,FICOG


Abstract
 
Background: To elucidate the possible role of human cytomegalovirus in pregnancy loss through induction of certain pro-inflammatory adhesion molecules.
Methods: Paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein and VCAM-1 molecule.
Results: Nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a  significantly higher expression of VCAM-1 in HCMV positive cases as compared with HCMV negative and the control groups (p = 0.05, 0.001 respectively).



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